183. Kalhor, H. R., and Clarke,
S. (2003)
"Novel Methyltransferase for Modified Uridine Residues at the Wobble
Position of tRNA" Mol. Cell Biol. 23, 9283- 9292.
182. Katz, J. E., Dlakic,
M., and Clarke, S. (2003) "Automated
Identification of Putative Methyltransferases from Genomic Open Reading
Frames" Mol. Cell. Proteomics 2, 525-540.
181. Clarke, S. (2003) "Aging
as War Between Chemical and Biochemical Processes: Protein Methylation
and the Recognition of Age-Damaged Proteins for Repair" Ageing Res.
Rev. 2, 263-285.
180. Mura, C., Katz, J. E., Clarke, S. G., and Eisenberg, D. (2003)
"Structure and Function of an Archaeal Homolog of Survival Protein E (SurE):
An Acid Phosphatase with Purine Nucleotide Specificity" J. Mol. Biol.
326, 1559-1575.
179. Farrar, C., and Clarke, S. (2002) "Altered
Levels of S-Adenosylmethionine and S-Adenosylhomocysteine in the Brains
of L-Isoaspartyl (D-Aspartyl) O-Methyltransferase-deficient Mice"
J. Biol. Chem. 277, 27856-27863.
178. Clarke, S., and Banfield, K. (2002) "Can
Elevated Plasma Homocysteine Levels Result in the Inhibition of Intracellular
Methyltransferases" in Chemistry and Biology of Pteridines and
Folates (Milstein, S., Kapatos, G., Levine, R. A., and Shane, B., eds),
pp. 557-562, Kluwer Academic Publishers, Boston.
177. Ryttersgaard, C., Griffith, S. C., Sawaya, M. R., MacLaren, D. C.,
Clarke, S., and Yeates, T. O. (2002)
"Crystal structure of human L-isoaspartyl methyltransferase"
J. Biol. Chem. 277, 10642-10646.
176. Clarke, S. (2002)
"Commentary: The Methylator Meets the Terminator" Proc.
Natl. Acad. Sci. U. S. A. 99, 1104-1106.
175. Frankel, A., Yadav, N., Lee, J., Branscombe, T. L., Clarke, S., and
Bedford, M. T. (2002) "The
Novel Human Protein Arginine N-Methyltransferase PRMT6 is a Nuclear Enzyme
Displaying Unique Substrate Specificity" J. Biol. Chem. 277, 3537-3543.
174. Thapar, N., Griffith, S., Yeates, T. O., and Clarke, S. (2002)."Protein
Repair Methyltransferase from the Hyperthermophilic Archaeon Pyrococcus
furiosus: Unusual Methyl-accepting Affinity for D-Aspartyl and N-Succinyl-
containing Peptides" J. Biol. Chem. 277, 1058-1065.
173. Kalhor, H. R., Luk, K., Ramos, A., Zobel-Thropp, P., and Clarke,
S. (2001)
"Protein Phosphatase Methyltransferase 1 (PPM1) is the Sole Activity Responsible
for Modification of the Major forms of Protein Phosphatase 2A in Yeast"
Arch. Biochem. Biophys. 395, 239-245.
172. Cai, H., Dumlao, D., Katz, J. E. , and Clarke, S. (2001) "Identification
of the Gene and Characterization of the Activity of the trans-Aconitate
Methyltransferase from Saccharomyces cerevisiae" Biochemistry 40,
13699- 13709.
171. Griffith, S. C., Sawaya, M. R., Boutz, D. R., Thapar, N., Katz, J.
E., Clarke, S., and Yeates, T. O. (2001) "Crystal
Structure of a Protein Repair Methyltransferase from Pyrococcus furiosus
with its L-Isoaspartyl Peptide Substrate" J. Mol. Biol. 313, 1103-1116.
170. Zhang, R.-G., Skarina, T., Katz, J. E., Beasley, S., Khachatryan,
A., Vyas, S., Arrowsmith, C. H., Clarke, S., Edwards, A., Joachimiak,
A., and Savchenko, A. (2001) "Structure
of Thermotoga maritima SurE - Stationary Phase Survival Protein - a Novel
Acid Phosphatase" Structure 9, 1095-1096.
169. Branscombe, T. L., Frankel, A., Lee, J.-H., Cook, J. R., Yang, Z.,
Pestka, S., and Clarke, S. (2001)
"PRMT5 (the Janus Kinase Binding Protein 1) Catalyzes the Formation of
Symmetric Dimethylarginine Residues in Proteins" J. Biol. Chem. 276,
32971-32976.
168. Clarke, S., and Banfield, K. (2001) "S-Adenosylmethionine-dependent
Methyltransferases" in Homocysteine in Health and Disease (Carmel,
R., and Jacobsen, D., eds), pp. 63-78.
167. Lowenson, J. D., Kim, E., Young, S. G., and Clarke, S. (2001) "Limited
Accumulation of Damaged Proteins in L-Isoaspartyl (D-Aspartyl) O- Methyltransferase-deficient
Mice" J. Biol. Chem. 276, 20695-20702.
166. Radkiewicz, J. L., Zipse, H., Clarke, S., and Houk, K. N. (2001)
"Neighboring
Side Effects on Asparaginyl and Aspartyl Degradation: An Ab Initio Study
of the Relationship Between Peptide Conformation and Backbone NH Acidity"
J. Amer. Chem. Soc. 123, 3499-3506.
165. Cai, H., Strouse, J., Dumlao, D., Jung, M. E., and Clarke, S. (2001)
"Distinct
Reactions Catalyzed by Bacterial and Yeast trans-Aconitate Methyltransferases"
Biochemistry 40, 2210-2219.
164. Thapar, N., Kim, A.-K., and Clarke, S. (2001) "Distinct
Patterns of Expression but Similar Biochemical Properties of Protein L-Isoaspartyl
Methyltransferases in Plants" Plant Physiol. 125, 1023-1035.
163. Zobel-Thropp, P., Yang, M. C., Machado, L., and Clarke, S. (2000)
"A Novel Post-translational Modification of Yeast Elongation Factor 1A:
Methylesterification at the C-Terminus" J. Biol. Chem. 275, 37150-37158.
162. Thapar, N., and Clarke, S. (2000) "Expression,
Purification, and Characterization of the Protein Repair L-Isoaspartyl
Methyltransferase from Arabidopsis thaliana" Protein Expression Purification
20, 237-251.
161. Frankel, A., and Clarke, S. (2000)
"PRMT3 is a Distinct Member of the Protein Arginine N-Methyltransferase
Family: Conferral of Substrate Specificity by a Zinc-Finger Domain"
J. Biol. Chem. 275, 32974-32982.
160. Yan, S. D., Zhu, Y., Zhu, H., Stern, E. D., Hwang, Y. C., Hori, O.,
Ogawa, S., Frosch, M. P., Connolly, E. S., Jr., McTaggert, R., Pinsky,
D. J., Clarke, S., Stern, D. M., and Ramasamy, R. (2000) "Amyloid
Beta-Peptide Binding Alcohol Dehydrogenase is a Component of the Cellular
Response to Nutritional Stress" J. Biol. Chem. 275, 27100-27109.
159. Young, S. G., Ambroziak, P., Kim, E., and Clarke, S. (2000) "Post-
isoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine
Carboxyl Methyltransferase" in Protein Lipidation, a volume of The
Enzymes, 3rd edition (Tamanoi, F., and Sigman, D. S., eds), 21, 155-213.
158. Bedford, M. T., Frankel, A., Yaffe, M. B., Clarke, S., Leder, P.
and Richard, S. (2000) "Arginine
Methylation Inhibits the Binding of Proline- rich Ligands to Src Homology
3, but not WW Domains" J. Biol. Chem. 275, 16030-16036.
157. Tang, J., Frankel, A., Cook, R. J., Kim S., Paik, W. K., Williams,
K. R., Clarke, S., and Herschman, H. R. (2000)
"PRMT1 is the Predominant Type I Protein Arginine Methyltransferase in
Mammalian Cells" J. Biol. Chem. 275, 7723-7730.
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