Steven Clarke Lab Publications - 1996 - 1999
156. Lowenson, J. D., Clarke, S., and Roher, A. E. (1999) "Chemical Modifications of Deposited Ab Peptides" Methods Enzymol. 309, 89-105.

155. Kalhor, H. R., Niewmierzycka, A., Faull, K. F., Yao, X., Grade, S., Clarke, S., and Rubenstein, P. A. (1999) "A Highly Conserved 3-Methylhistidine Modification is Absent in Yeast Actin" Arch. Biochem. Biophys. 370, 105-111.

154. DeVry, C. G., and Clarke, S. (1999) "Polymorphic Forms of the Protein L- Isoaspartate (D-Aspartate) Methyltransferase Involved in the Repair of Age- Damaged Proteins" J. Hum. Genetics 44, 275-288.

153. Clarke, S. (1999) "A Protein Carboxyl Methyltransferase that Recognizes Age- Damaged Peptides and Proteins and Participates in their Repair" in S- Adenosylmethionine-dependent Methyltransferases: Structures and Function" (Cheng, X, and Blumenthal, R. M., eds) World Scientific Publishing Company, Singapore, pp. 123-140.

152. Kim, E., Lowenson, J. D., Clarke, S., and Young, S. G. (1999) "Phenotypic Analysis of Seizure-Prone Mice Lacking L-Isoaspartate (D-Aspartate) O- Methyltransferase" J. Biol. Chem. 274, 20671-20678.

151. Frankel, A., and Clarke, S. (1999) "RNase Treatment of Yeast and Mammalian Cell Extracts Affects In Vitro Substrate Methylation by Type I Protein Arginine N-Methyltransferases" Biochem. Biophys. Res. Commun. 259, 391-400.

150. DeVry, C. G., and Clarke, S. (1999) "Assignment of the Protein L- Isoaspartate (D-Aspartate) O-Methyltransferase gene (PCMT1) to human chromosome bands 6q24-q25 with radiation hybrid mapping" Cytogenet. Cell. Gen. 84, 130-131.

149. Cai, H., and Clarke, S. (1999) "A Novel Methyltransferase Catalyzes the Methyl Esterification of trans-Aconitate in Escherichia coli" J. Biol. Chem. 274, 13470-13479.

148. Niewmierzycka, A., and Clarke, S. (1999) "Do Damaged Proteins Accumulate in Caenorhabditis elegans L-Isoaspartate Methyltransferase (pcm-1) Deletion Mutants?" Arch. Biochem. Biophys. 364, 209-218. 

147. Yan, S.-D., Shi, Y., Zhu, A., Fu, J., Zhu, H., Zhu, Y., Gibson, L., Stern, E., Collison, K., Al-Mohanna, F., Ogawa, S., Roher, A., Clarke, S. G., and Stern, D. (1999) "Role of ERAB/L-3-Hydroxyacyl-Coenzyme A Dehydrogenases Type II Activity in Ab-Induced Cytotoxicity" J. Biol. Chem. 274, 2145-2156.

146. Niewmierzycka, A., and Clarke, S. (1999) "S-Adenosylmethionine-dependent Methylation in Saccharomyces cerevisiae: Identification of a Novel Protein Arginine Methyltransferase" J. Biol. Chem. 274, 814-824.

145. Zobel-Thropp, P. Gary, J. D., and Clarke, S. (1998) "d-N-Methylarginine Is A Novel Posttranslational Modification of Arginine Residues in Yeast Proteins" J. Biol. Chem. 273, 29283-29286.

144. Ichikawa, J. K., and Clarke, S. (1998) "A Highly Active Protein Repair Enzyme from an Extreme Thermophile: The L-Isoaspartyl Methyltransferase from Thermotoga maritima" Arch. Biochem. Biophys. 358, 222-231.

143. Visick, J. E., Ichikawa, J. K., and Clarke, S. (1998) "Mutations in the Escherichia coli surE Gene Increase Isoaspartyl Accumulation in a Strain Lacking the pcm Repair Methyltransferase but Suppress Stress-survival Phenotypes" FEMS Microbiol. Lett. 167, 19-25.

142. Gary, J. D., and Clarke, S. (1998) "RNA and Protein Interactions Modulated by Protein Arginine Methylation" Prog. Nucl. Acid Res. Mol. Biol. 61, 65-130. 

141. Tang, J, Gary, J. D., Clarke, S., and Herschman, H. R. (1998) "PRMT3, a Type I Protein Arginine N-Methyltransferase that Differs from PRMT1 in its Oligomerization, Subcellular Localization, Substrate Specificity and Regulation" J. Biol. Chem. 273, 16935-16945. 

140. Gary, J. D., and Clarke, S. (1998) "b-Aspartyl Dipeptidase" in Handbook of Proteolytic Enzymes, (eds. Woessner, G., Rawlings, N., and Barrett, A. J.), Academic Press, New York, pp. 1461-1465.

139. Visick, J. E., Cai, H., and Clarke, S. (1998) "The L-Isoaspartyl Protein Repair Methyltransferase Enhances Survival of Aging Escherichia coli Subjected to Secondary Environmental Stresses" J. Bacteriol. 180, 2623-2629.

138. Kagan, R. M., Niewmierzycka, A., and Clarke, S. (1997) "Targeted Gene Disruption of the Caenorhabditis elegans L-Isoaspartyl Protein Repair Methyltransferase Impairs Survival of Dauer Stage Nematodes" Arch. Biochem. Biophys. 348, No. 2, Dec. 15, 320- 328.

137. Mudgett, M. B., Lowenson, J. D., and Clarke, S. (1997) "Protein Repair L- Isoaspartyl Methyltransferase in Plants: Phylogenetic Distribution and the Accumulation of Substrate Proteins in Aged Barley Seeds" Plant Physiol. 115, 1481-1489.

136. David, C. L., Szumlanski, C. L., DeVry, C. G., Park-Hah, J. O., Clarke, S., Weinshilboum, R. M., and Aswad, D. W. (1997) "Human Erythrocyte Protein L- Isoaspartyl Methyltransferase: Heritability of Basal Activity and Genetic Polymorphism for Thermal Stability" Arch. Biochem. Biophys. 346, 277-286.

135. Kagan, R. M., McFadden, H. J., McFadden, P. N., O'Connor, C. M., and Clarke, S. (1997) "Molecular Phylogenetics of a Protein Repair Methyltransferase" Comp. Biochem. Physiol. 117B, 379-385.

134. Visick, J. E., and Clarke, S. (1997) "RpoS- and OxyR-Independent Induction of HPI Catalase at Stationary Phase in Escherichia coli and Identification of rpoS Mutations in Common Laboratory Strains" J. Bacteriol. 179, 4158- 4163.

133. Kim, E., Lowenson, J. D., MacLaren, D. C., Clarke, S., and Young, S. G. (1997) "Deficiency of a Protein-Repair Enzyme Results in the Accumulation of Altered Proteins, Retardation of Growth, and Fatal Seizures in Mice" Proc. Natl. Acad. Sci. U. S. A. 94, 6132-6137.

132. Perna, A. F., D'Aniello, A., Lowenson, J. D., Clarke, S., De Santo, N. G., and Ingrosso, D. (1997) "D-Aspartate Content of Erythrocyte Membrane Proteins is Decreased in Uremia: Implications for the Repair of Damaged Proteins" J. Amer. Soc. Nephrol. 8, 95-104.

131. DeVry, C. G., Tsai, W., and Clarke, S. (1996) "Structure of the Human Gene Encoding the Protein Repair L-Isoaspartyl (D-Aspartyl) O- Methyltransferase" Arch. Biochem. Biophys. 335, 321-332.

130. Radkiewicz, J. L., Zipse, H., Clarke, S., and Houk, K. N. (1996) "Accelerated Racemization of Aspartic Acid and Asparagine Residues via Succinimide Intermediates: An ab Initio Theoretical Explanation of Mechanism" J. Amer. Chem. Soc. 118, 9148-9155.

129. MacLaren, D. C., and Clarke, S. (1996) "Rapid Mapping of Genomic P1 Clones: The Mouse L-Isoaspartyl/D-Aspartyl Methyltransferase Gene" Genomics, 35, 299-307.

128. Lin, W.-J., Gary, J. D., Yang, M. C., Clarke, S., and Herschman, H. R. (1996) "The Mammalian Immediate-Early TIS21 Protein and the Leukemia- Associated BTG1 Protein Interact with a Protein Arginine N- Methyltransferase" J. Biol. Chem. 271, 15034-15044.

127. Gary, J. D., Lin, W.-J., Yang, M. C., Herschman, H., and Clarke, S. (1996) "The Predominant Protein Arginine Methyltransferase from Saccharomyces cerevisiae" J. Biol. Chem. 271, 12585-12594.

126. Mudgett, M. B., and Clarke, S. (1996) "A Distinctly-Regulated Protein Repair L-Isoaspartyl Methyltransferase from Arabidopsis thaliana" Plant Mol. Biol. 30, 723-737.