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James
U. Bowie
Professor
Membrane protein structure and folding; polymerizing protein modules for the construction of large macromolecular structures
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Office
- (310) 206-4747
Lab - (310) 206-4748
Fax - (310) 206-4749
655 Boyer Hall
bowie@mbi.ucla.edu
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Guillaume
Chanfreau
Associate Professor
RNA processing and metabolism in eukaryotes; RNA-Protein interactions;
RNA endonucleases
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Office
- (310) 825-4399
Lab - (310) 825-8412
4042A Young Hall
guillom@chem.ucla.edu
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Catherine
F. Clarke
Professor
Biosynthesis, regulation and function of ubiquinone (coenzyme
Q); characterization of genes in the ubiquinone biosynthetic pathway;
interspecific complementation of yeast ubiquinone mutants;
anti-oxidant defense mechanisms
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Steven
G. Clarke
Professor
Protein methylation reactions in eukaryotic
cells; non-enzymatic degradation reactions of proteins; biochemistry
of aging; signal transduction
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Robert
T. Clubb
Associate
Professor
Mechanisms of bacterial pathogenesis; Function of cell surface virulence factors in Staphylococcus aureus and Bacillus anthracis; Heteronuclear multidimensional NMR spectroscopy; Mechanisms of recombination
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Albert
J. Courey
Professor
Transcriptional regulation; biochemical and molecular genetic analysis
of pattern formation during fruit fly embryogenesis
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David
S. Eisenberg
Professor
Study of biochemical macromolecules by X-ray diffraction and computational
methods; structure and action of enzymes and of membrane-related
proteins; protein folding and the atomic basis of biological recognition
National Academy of Sciences Member
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Juli
Feigon
Professor
Conformational studies of nucleic acids using multidimensional NMR
techniques: DNA triplexes and quadruplexes; drug-DNA complexes,
DNA and RNA aptamers; DNA and RNA-protein complexes
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Office
- (310) 206-6922
Lab - (310) 825-9232
Fax - (310) 825-0982
256 Boyer Hall
feigon@mbi.ucla.edu
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James
W. Gober
Professor
Transcriptional regulation during cell differentiation in Caulobacter;
genetics and biochemistry of cell cycle and polar gene expression;
DNA higher-order structure and transcriptional activation; chromosome
structure
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Jay
D. Gralla
Professor
The role of nucleic acid-protein complexes in cellular controls;
repression and activation of transcription; mechanism of action
of anti-cancer drugs that attack DNA; chemical probes of DNA structure
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Wayne
L. Hubbell
Professor
Molecular mechanisms of membrane transduction and switching processes,
primarily visual transduction and voltage dependent membrane gating
systems. Development of spectroscopic approaches for the study of
membrane structure, dynamics and electrostatic phenomena
National Academy of Sciences Member
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Carla
M. Koehler
Associate Professor
Genetic and biochemical studies of protein import into mitochondria,
role of mitochondrial biogenesis in cellular functions and disease
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Christopher
J. Lee
Professor
Bioinformatics and genomics: genome sequence analysis; computational
methods for identification of single nucleotide polymorphisms; genomics
databases; prediction of protein structure and function
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Joseph
A. Loo
Professor
Development
of novel bioanalytical methods for the characterization of proteins
and their post-translational modifications and their application
for drug discovery and proteomics. Development
and application of electrospray ionization mass spectrometry for
the study of noncovalently-bound macromolecular complexes and their
interactions with inhibitors. Fundamentals
of analytical chemistry and mass spectrometry.
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Parag Mallick
Adjunct Assistant Professor
Our group primarily develops and applies systems approaches to
quantitatively describe organisms' physiologic states. Applications
include enabling personalized, predictive medicine. Specifically, we
are developing experimental techniques and computational methods for
quantitative proteomic profiling and pattern discovery. In addition,
we are developing tools to integrate genomic information with
proteomic information so as to better elucidate the genome and to
develop more detailed models of regulation.
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Harold
G. Martinson
Professor
Coupling of RNA processing with transcription in eukaryotes: splicing; cleavage & polyadenylation; poly(A)-dependent pausing and termination.
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Sabeeha
Merchant
Professor
Copper and iron homeostasis; re-modelling of the photosynthetic
apparatus in iron-deficiency; mechanisms of copper sensing and signal
transduction; cytochrome c biogenesis; chloroplast metabolism; photosynthesis
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Margot Quinlan
Assistant Professor -- joining the department in July 2008!
Dynamics of the actin cytoskeleton; the role of Spire and Cappuccino in
regulating actin and oogenesis; biochemistry, genetics and microscopy |
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Emil
Reisler
Professor
Structure and function of contractile proteins; protein-protein
and protein-ligand interactions; mechanism of muscle contraction;
mechanism of ATP hydrolysis; self assembly of myosin and actin
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Joan
S. Valentine
Professor
Bioinorganic chemistry study of the reactivity and other properties
of transition metal complexes that are analogues of metalloenzyme
active sites; study of structure-function relationships in the enzyme
copper-zinc superoxide dismutase using site-directed utagenesis;
biochemistry of oxygen, superoxide, and peroxide
National Academy of Sciences Member
Editor-in-Chief, Accounts of Chemical Research
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Office
- (310) 825-9835
Lab - (310) 825-2807
Fax - (310) 206-9880
4037 Young Hall
jsv@chem.ucla.edu
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Richard
L. Weiss
Professor
Compartmentation of enzymes and metabolites; molecular genetics,
metabolic and genetic regulation in eukaryotic microorganisms
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Todd
O. Yeates
Professor
Three-dimensional structure and function of proteins by X-ray diffraction;
computational analysis of macromolecules
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Daniel
E. Atkinson
Professor Emeritus
Cellular
energy metabolism and its regulation
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Office
- (310) 825-1159
2069 Young Hall
dea@ucla.edu
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Paul
D. Boyer
Professor Emeritus
Bioenergetics of ATP synthesis
1997 Nobel Prize Winner
National Academy of Sciences Member
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Richard E. Dickerson
Professor Emeritus
X-ray studies of nucleic acids and proteins; sequence/structure relationships in double-helical DNA; binding of anti-tumor drugs and recognition proteins to DNA; evolution of macromolecules and metabolic pathways
National Academy of Sciences Member
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Verne
N. Schumaker
Professor Emeritus
Surface architecture of serum lipoproteins using monoconal antibodies,
and the structure of the gene coding for apolipoprotein B; mechanism
of activation of the first component of complement, and the role
of segmental flexibility in the immune system; expression of complement
proteins
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Roberts
A. Smith
Professor Emeritus
Phosphorus-nitrogen bonds in proteins;mechanisms of antiviral agents
and methionine and folic acid metabolism in normal and malignant
cells
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Charles
A. West
Professor Emeritus
Plant biochemistry; regulation of the biosynthesis of isoprenoid
compounds with physiological activity including disease resistance
agents and the gibberellin family of growth regulators; diterpene
metabolism, studies of molecular mechanisms involved in plant disease
resistance
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