HOME

RESEARCH PROJECTS

GALLERY

PUBLICATIONS

NMR FACILITY

LAB MEMBERS

ALUMNI

NEWS

JULI FEIGON
Professor of Biochemistry; Postdoc, Massachusetts Institute of Technology; B.A., Occidental College; M.S. and Ph.D. University of California, San Diego.

Member of the National Academy of Sciences.

Dept. of Chemistry and Biochemistry

University of California, Los Angeles

607 Charles Young Dr. East

P.O. Box 951569
Los Angeles, CA  90095-1569

Office Phone: 310-206-6922
Lab Phone: 310-825-9232
Fax: 310-825-0982
feigon@mbi.ucla.edu

 

 

Nucleic Acid Chime Demos

153BH Honors Projects

 

JOIN OUR LAB!

 

 

 

 

 

 

 

 

 

Nucleic acid structure and function

RNA has increasingly been found to have a role in everything from regulation of transcription and translation to synthesis of the ends of chromosomes to enzymatic reactions. In order to do these things, RNA assumes a variety of shapes and often forms specific RNA-protein complexes. DNA can also adopt a variety of conformations besides the Watson-Crick double helix, and its interactions with proteins are vital to regulation of replication, transcription, and repair. My laboratory studies the structure and function of DNA and RNA primarily using multidimensional nuclear magnetic resonance (NMR) spectroscopy, which provides a method for determining the three-dimensional structures of macromolecules and to study their dynamics in solution. In addition to NMR spectroscopy, we use X-ray crystallography, small angle X-ray scattering, and cryoelectron microscopy for our structural studies. Structural and dynamics information is correlated with function using a variety of biochemical and molecular biological techniques, to provide insight into how these nucleic acids and nucleic acid-protein complexes work in the cell and how mutations in RNA and DNA can lead to disease. Currently, the research in my laboratory is focused on three major topics: (1) the structure and function of telomerase, (2) biogenesis of H/ACA RNPs, and (3) riboswitch structure and dynamics.

(
Detailed Research Projects)

 

 

Web Design:

Evan Feinstein

 

Internal Page