Publications
2021-present
188) Palumbo R, Yang Y, Feigon J, Hanes S.: "Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster", Genetics. 226(1) (2024). [PubMed]
187) Wang Yaqiang, He Y, Wang Yanjiao, Yang Y, Singh M, Eichhorn CD, Cheng X, Jiang Y, Zhou ZH, Feigon J.: "Structure of LARP7 Protein p65–telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR", J. Mol. Biol. 256, 417-422 (2023). [PubMed]
186) He Y, Feigon J.: "Telomerase structural biology comes of age", Curr Opin Struct Biol. 76 (102446) (2022).[PubMed]
185) He Y, Song H, Chan H, Liu B, Wang Y, Sušac L, Zhou ZH, Feigon J.: "Structure of Tetrahymena telomerase-bound CST with polymerase α-primase", Nature. 608(7924):813-818 (2022) [PubMed]
184) Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J.: "Structure of active human telomerase with telomere shelterin protein TPP1", Nature. 604(7906):578–583 (2022) [PubMed]
183) Yang Y, Liu S, Egloff S, Eichhorn CD, Hadjian T, Zhen J, Kiss T, Zhou ZH, Feigon J.: "Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP", Mol Cell. S1097-2765(22)00210-6 (2022)[PubMed]
182) He Y, Wang Y, Liu B, Helmling C, Sušac L, Cheng R, Zhou ZH, Feigon J.: "Structures of telomerase at several steps of telomere repeat synthesis", Nature. 593(7859):454-459 (2021). [PubMed]
2016-2020
181) Wang Y, Gallagher-Jones M, Sušac L, Song H, Feigon J.: "A structurally conserved human and Tetrahymena telomerase catalytic core", Proc Natl Acad Sci U S A. 117(49):31078-31087 (2020). [PubMed]
180) Basu R, Eichhorn CD, Cheng R, Peterson RD, Feigon J: "Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins", RNA Biol. 1:1-12 (2020). [PubMed]
179) Wang Y, Sušac L, Feigon J: "Structural Biology of Telomerase.", Cold Spring Harb Perspect Biol. 11(12):a032383 (2019). [PubMed]
178) Yang Y, Eichhorn CD, Wang Y, Cascio D, Feigon J: "Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE", Nat Chem Biol. 15(2):132-140 (2019). [PubMed]
177) Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L: "Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design", Nat Chem. 10(12):1267 (2018). [PubMed]
176) Eichhorn CD, Yang Y, Repeta L, and Feigon J: "Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7", Proc Natl Acad Sci U S A. 115(28):E6457-E6466 (2018). [PubMed] [F1000]
175) Jiang J, Wang Y, Sušac L, Chan H, Basu R, Zhou ZH, and Feigon J: "Structure of Telomerase with Telomeric DNA", Cell. 173(5):1179-1190.e13 (2018). [PubMed] [F1000] [PDB Molecule of the Month]
174) Wang Y and Feigon J: "Structural biology of telomerase and its interaction at telomeres", Curr Opin Struct Biol. 47:77-87 (2017). [PubMed]
173) Chan H, Wang Y, Feigon J: "Progress in Human and Tetrahymena Telomerase Structure Determination", Annu Rev Biophys. 46:199-225 (2017). [PubMed]
172) Cash DD, Feigon J: "Structure and folding of the Tetrahymena telomerase RNA pseudoknot", Nucleic Acids Res. 45(1):482-495 (2017). [PubMed]
171) Upton HE, Chan H, Feigon J, Collins K: "Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes.", J Biol. Chem. 292(1):217-228 (2017). [PubMed]
170) Eichhorn CD, Chug R, Feigon J: "hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA", Nucleic Acids Res. 16;44(20):9977-9989 (2016). [PubMed]
169) Wang Y, Yesselman JD, Zhang Q, Kang M, Feigon J: "Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human", Proc Natl Acad Sci U S A. 113(35):E5125-34 (2016). [PubMed]
168) Feigon J, Chan H, Jiang J: "Integrative structural biology of Tetrahymena telomerase: insights into catalytic mechanism and interaction at telomeres", FEBS J. 283(11):2044-50 (2016). [PubMed]
2011-2015
167) Jiang J, Chan H, Cash DD, Miracco EJ, Ogorzalek Loo RR, Upton HE, Cascio D, O'Brien Johnson R, Collins K, Loo JA, Zhou ZH, Feigon J: "Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions", Science. 350(6260):aab4070 (2015). [PubMed]
166) Feigon J: "Back to the future of RNA structure", RNA. 21(4):611-2 (2015). [PubMed]
165) Singh M, Wang Z, Cascio D, Feigon J: "Structure and interactions of the CS domain of human H/ACA RNP assembly protein Shq1", J Mol Bio. 427(4):807-23 (2015). [PubMed]
164) Eichhorn CD, Kang M, Feigon J: "Structure and function of preQ1 riboswitches", Biochim Biophys Acta. pii: S1874-9399(14)00102-3 (2014). [PubMed]
163) Kang M, Eichhorn CD, Feigon J: "Structural determinants for ligand capture by a class II preQ1 riboswitch", Proc Natl Acad Sci U S A. 111(6):E663-71 (2014). [PubMed]
162) Miracco EJ, Jiang J, Cash DD, Feigon J: "Progress in structural studies of telomerase", Curr. Opin. Struct. Biol. 24C:115-124 (2014). [PubMed]
161) Kim NK, Zhang Q, Feigon J: "Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function", Nucleic Acids Res. 42(5): 3395-3408 (2014). [PubMed]
160) Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO: "Molecular mechanism of GTPase activation at the SRP RNA distal end", J Biol Chem. 288(51):36385-97 (2013). [PubMed]
159) Hong K, Upton H, Miracco EJ, Jiang J, Zhou ZH, Feigon J, Collins K: "Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub", Mol Cell Biol. 33(19):3962-71 (2013). [PubMed]
158) Cash DD, Cohen-Zontag O, Kim NK, Shefer K, Brown Y, Ulyanov NB, Tzfati Y, Feigon J: "Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo", Proc Natl Acad Sci U S A. 110(27):10970-5 (2013). [PubMed]
157) Jiang J, Miracco EJ, Hong K, Eckert B, Chan H, Cash DD, Min B, Zhou ZH, Collins K, Feigon J: "The architecture of Tetrahymena telomerase holoenzyme", Nature. 496(7444):187-92 (2013).[PubMed] [Nature News] [F1000]
156) Hartman E, Wang Z, Zhang Q, Roy K, Chanfreau G, Feigon J: "Intrinsic dynamics of an extended hydrophobic core in the S. cerevisiae RNase III dsRBD contributes to recognition of specific RNA binding sites", J Mol Biol. 425(3):546-62 (2013). [PubMed]
155) Singh M, Choi CP, Feigon J: "xRRM: A new class of RRM found in the telomerase La family protein p65", RNA Biol. 10(3) (2013). [PubMed]
154) Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J: “Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4 T) in the presence of Cs+ ions”, Angew Chem Int Ed Engl. 51(32):7952-5 (2012). [PubMed]
153) Singh M, Wang Z, Koo BK, Patel A, Cascio D, Collins K, Feigon J: “Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65”, Mol Cell. 47(1):16-26 (2012). [PubMed]
152) Hengesbach M, Kim NK, Feigon J, Stone MD: “Single-molecule FRET reveals the folding dynamics of the human telomerase RNA pseudoknot domain”, Angew Chem Int Ed Engl. 51(24):5876-9 (2012). [PubMed]
151) Q. Zhang, N.-K. Kim, and J. Feigon: “The architecture of human telomerase RNA”, Proc. Natl. Acad. Sci. 108(51):20325-32 (2011). [PubMed]
150) B.-K. Koo, C.-J. Park, C.F. Fernandez, N. Chim, Y. Ding, G. Chanfreau, and J. Feigon: “Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface”, J. Mol. Biol. 411, 927-942 (2011). [PubMed]
149) Z. Wang, E. Hartman, K. Roy, G. Chanfreau, and J. Feigon: “Structure of a yeast RNase III dsRBD complex with a non-canonical RNA substrate provides insights into binding specificity of dsRBDs”, Structure 19, 999-1010 (2011). [PubMed]
148) Q. Zhang, M. Kang, R.D. Peterson, and J. Feigon: “Comparison of solution and crystal structure of preQ1 riboswitch reveals calcium induced changes in conformation and dynamics”, J. Am. Chem. Soc. 133, 5190-5193 (2011). [PubMed]
2006-2010
147) Q. Zhang, N.-K. Kim, R.D. Peterson, Z. Wang, and J. Feigon: “Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA”, Proc. Natl. Acad. Sci. USA 107, 18761-18768 (2010). [PubMed] [F1000]
146) N.-K. Kim, C.A. Theimer, J.R. Mitchell, K. Collins, and J. Feigon, "Effect of pseudouridylation on the structure and activity of the catlytically essential P6.1 hairpin in human telomerase RNA", Nucleic Acids Res., 38, 6746-6756 (2010). [PubMed]
145) M. Kang, R. Peterson, and J. Feigon, "Structural insights into riboswitch control of the biosynthesis of queuosine, a modified nucleotide found in the anticodon of tRNA", Mol. Cell, 33, 784-790 (2009). [PubMed] [F1000]
144) M. Singh, F.A. Gonzales, D. Cascio, N. Heckmann, G. Chanfreau, and J. Feigon, "Structure and functional studies of the CS domain of the essential H/ACA RNP assembly protein Shq1", J. Biol. Chem., 284, 1906-1916 (2009). [PubMed]
143) N.-K. Kim, Q. Zhang, J. Zhou, C.A. Theimer, R.D. Peterson, and J. Feigon: "Solution structure and dynamics of the wild-type pseudoknot of human telomerase RNA" J. Mol. Biol. 384, 1249-1261 (2008). [PubMed]
142) C.A. Theimer, B.E. Jady, N. Chim, P. Richard, K.E. Breece, T. Kiss, and J. Feigon: “Structural and functional characterization of human telomerase RNA processing and Cajal Body localization signals” Molecular Cell 27, 869-881 (2007). [PubMed]
141) K. Januszyk, P.W. Li, V. Villareal, D. Branciforte, H. Wu, Y. Xie, J. Feigon, J.A. Loo, S.L. Martin, and R.T. Clubb: "Identification and solution structure of a highly conserved C-terminal domain required for the retrotransposition of Long Interspersed Nuclear Element-1" J. Biol. Chem. 282, 24893-24904 (2007). [PubMed]
140) H. Wu and J. Feigon: "H/ACA small nucleolar RNA pseudouridylation pockets bind substrate RNA to form three-way junctions that position the target U for modification" PNAS 104, 6655-6660 (2007). [PubMed] [F1000]
139) R.J. Richards, H. Wu, L. Trantirek, C.M. O'Connor, k. Collins, and J. Feigon: "Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function" RNA 12, 1475-1485 (2006). [PubMed]
138) C.A. Theimer and J. Feigon: "Structure and function of telomerase RNA", Curr. Opin. Struct. Biol. 16, 307-318 (2006). [PubMed]
137) R.J. Richards, C.A. Theimer, L.D. Finger, and J. Feigon: "Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element", Nucleic Acids Res. 34, 816-825 (2006). [PubMed]
136) M. Khanna, H. Wu, C. Johansson, M. Caizergues-Ferrer, and J. Feigon, "Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA", RNA 12, 40-52 (2006). [PubMed]
2001-2005
135) A.J. Dingley, R.D. Peterson, S. Grzesiek, and J. Feigon, "Characterization of the cation and temperature dependence of DNA quadruplex hydrogen bond properties using high-resolution NMR", J. Am. Chem. Soc. 127, 14466-72 (2005). [PubMed]
134) A.K. Henras, M. Sam, S.L. Hiley, H. Wu, J. Feigon, T.R. Hughes, and G.F. Chanfreau: “Biochemical and genomic and analysis of substrate recognition by the double stranded RNA binding domain of yeast RNase III”, RNA 11, 1225-1237 (2005). [PubMed]
133) P.Z. Qin, J. Feigon, and W. Hubbell: “Site-directed spin labeling studies reveal a coupled mechanism in the formation of the GAAA tetraloop/receptor RNA tertiary interaction”, J. Mol. Biol. 351, 1-8 (2005). [PubMed]
132) H. Wu, L.D. Finger, J. Feigon: “Structure determination of Protein/RNA complexes by NMR”, in Methods in Enzymol. (T.L. James, ed.) Academic Press, 394, 525-545 (2005). [PubMed]
131) C.A. Theimer, C.A. Blois, and J. Feigon: “Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function”, Mol. Cell 17, 671-682 (2005). [PubMed] [F1000]
130) M. Kamionka and J. Feigon: "Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction", Protein Science, 13, 2370-2377 (2004). [PubMed]
129) J. Feigon and C. Bustamante: “Nucleic acids – controlling biology and controlled by biophysics” Curr. Opin. Struct. Biol., 14, 333-334 (2004).
128) L.D. Finger, C. Johansson, B. Rinaldi, P. Bouvet, and J. Feigon "Contributions of the RBDs and linker domains and RNA structure to the specificity and affinity of the nucleolin RBD12/NRE interaction" Biochemistry, 43, 6937-6947 (2004). [PubMed]
127) H. Wu, A. Henras, G. Chanfreau, and J. Feigon: “Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA binding domain of Rnt1p Rnase III”, Proc. Natl. Acad. Sci. USA, 101, 8307-8312 (2004). [PubMed] [F1000]
126) C. Johansson, L.D. Finger, L. Trantirek, T.D. Mueller, S. Kim, I.A. Laird-Offringa, and J. Feigon: “Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target”, J. Mol. Biol., 337, 799-816 (2004). [PubMed]
125) T.D. Mueller, M. Kamionka, and J. Feigon: “Specificity of the interaction between UBA domains and ubiquitin”, J. Biol. Chem., 279, 11926-11936 (2004). [PubMed]
124) R. Stefl, H. Wu, S. Ravindranathan, V. Sklenár, and J. Feigon: “DNA A-tract bending in three dimensions: Solving the dA4T4 versus dT4A4 conundrum”, Proc. Natl. Acad. Sci. USA, 101, 1177-1182 (2004). [PubMed] [F1000]
123) R.D. Peterson, C.A. Theimer, H. Wu, and J. Feigon: “New Applications of 2D Filtered/Edited NOESY for Assignment and Structure Elucidation of RNA and RNA-Protein Complexes”, J. Biomol. NMR, 28, 59-67 (2004). [PubMed]
122) C.A. Theimer, L.D, Finger, and J. Feigon: “YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA”, RNA, 9, 1446-1455 (2003). [PubMed]
121) L.D. Finger, L. Trantirek, C. Johansson, and J. Feigon: “Solution structures of stem-loop RNAs that bind to the two N-terminal RNA-binding domains of nucleolin”, Nucleic Acids Res., 31, 6461-6472 (2003). [PubMed] [F1000]
120) T.M. Mueller and J. Feigon: “Structural determinants for the binding of ubiquitin-like domains to the proteasome”, EMBO J., 22, 4634-4645 (2003). [PubMed]
119) P.Z. Qin, K. Hideg, J. Feigon, and W.L. Hubbell: "Monitoring RNA base structure and dynamics using site-directed spin labeling", Biochemistry, 42, 6772-6783 (2003). [PubMed]
118) C.A. Theimer, L.D. Finger, L. Trantirek, and J. Feigon: "Mutations linked to dyskeratosis congenita cause dynamic changes in telomerase RNA structure", Proc. Natl. Acad. Sci. USA 100, 449-454 (2003). [PubMed] [F1000]
117) J.E. Masse, B. Wong, Y-M. Yen, F.H.-T. Allain, R.C. Johnson, and J. Feigon: " The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding", J. Mol. Biol., 323, 263-284 (2002). [PubMed]
116) N.V. Hud and J. Feigon: "Characterization of divalent cation localization in the minor groove of AnTn and TnAn DNA sequence elements by 1H NMR spectroscopy and manganese(II)", Biochemistry, 41, 9900-9910 (2002). [PubMed]
115) T.D. Mueller and J. Feigon: "Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions", J. Mol. Biol., 319, 1243-1255 (2002). [PubMed]
114) L. Trantirek, R. Stefl, J.E. Masse, J. Feigon, and V. Sklenar: "Determination of the glycosidic torsion angles in uniformly 13C-labeled nucleic acids from vicinal coupling constants 3JC2/4-H1 and 3JC6/8-H1", J. Biomol. NMR, 23, 1-12 (2002). [PubMed]
113) B. Wong, J.E. Masse, Y.-M. Yen, P. Giannikopolous, J. Feigon, and R.C. Johnson: "Binding to cisplatin-modified DNA by the S. cervisiae HMGB proteinNhp6A", Biochemistry, 41, 5404-5414 (2002). [PubMed]
112) H. Wu, Pok K. Yang, S.E. Butcher, S. Kang, G. Chanfreau, and J. Feigon: "A novel family of RNA tetraloop structure forms the recognition site for S. cerevisiae RNase III", EMBO J., 20, 7240-7249 (2001). [PubMed]
111) L. Zidek,H. Wu, J. Feigon, and V. Sklenar: "Measurement of small scalar and dipolar couplings in purine and pyrimidine bases" , J. Biomol. NMR 21, 153-160 (2001). [PubMed]
110) J. Feigon, S.E. Butcher, L.D. Finger, and N.V. Hud: "Solution NMR probing of cation binding sites on nucleic acids", in Methods in Enzymology (T.L. James, V. Dötsch, and U. Schmitz, eds.), Academic Press, 338, 400-420 (2001). [PubMed]
109) D.M.J. Lilley and J. Feigon: "Nucleic Acids: From single molecules to ensembles - cations, junctions, folding, and catalysis" (editorial) Curr. Opin. Struct. Biol., 11, 273-274 (2001).
108) P.Z. Qin, S.E. Butcher, J. Feigon, and W.L. Hubbell: "Quantitative analysis of the isolated GAAA tetraloop/receptor interaction in solution: A site-directed spin-labeling study", Biochemistry, 40, 6929-6936 (2001).
107) P. Bouvet, F. H.-T. Allain, L.D. Finger, T. Dieckmann, and J. Feigon, "Recognition of pre-formed and flexible elements of an RNA stem-loop by nucleolin", J. Mol. Biol., 309, 763-775 (2001).
106) M. Barfield, A.J. Dingley, J. Feigon, and S. Grzesiek: "A DFT Study of the interresidue dependencies of scalar J-coupling and magnetic shielding in the hydrogen-bonding regions of a DNA triplex", J. Am. Chem. Soc., 123, 4014-4022 (2001).
1996-2000
105) S. Ravindranathan, S.E. Butcher, and J. Feigon: "Adenine protonation in domain B of the hairpin ribozyme", Biochemistry, 39, 16026-16032 (2000).
104) F. H.-T. Allain, P. Bouvet, T. Dieckmann, and J. Feigon: "Molecular basis of sequence specific recognition of pre-ribosomal RNA by nucleolin", EMBO J., 19, 6870-6881 (2000).
103) D. Rovnyak, M. Baldus, G. Wu, N.V. Hud, J. Feigon, and R.G. Griffin: "Localization of 23Na+ in a DNA Quadruplex by High Field Solid State NMR", J. Am. Chem Soc., 122, 11423-11429 (2000).
102) E. Withers-Ward, T.D. Mueller, I.S.Y. Chen, and J. Feigon: "Biochemical and Structural Analysis of the Interaction between the UBA(2) Domain of the DNA Repair Protein HHR23A and HIV-1 Vpr", Biochemistry, 39, 14103-14112 (2000).
101)L. Trantírek, M. Urbásek, R. Stefl, J. Feigon, and V. Sklenár: "A Method for Direct Determination of Helical Parameters in Nucleic Acids Using Residual Dipolar Couplings", J. Am. Chem. Soc., 122, 10454-10455 (2000).
100) F. H.-T. Allain, D.E. Gilbert, P. Bouvet, and J. Feigon: "Solution Structure of the Two N-Terminal RNA-Binding Domains of Nucleolin and NMR Study of the Interaction With its RNA Target", J. Mol. Biol., 303, 227-241 (2000).
99) A.J. Dingley, J.E. Masse, J. Feigon, and S. Grzesiek: "Characterization of the Hydrogen Bond Network in Guanosine Quartets by Internucleotide 3hJNC’ and 2hJNN Scalar Couplings", J. Biomol. NMR, 16, 279-289 (2000).
98) S.E. Butcher, F.H.-T. Allain, and J. Feigon: "Determination of Metal Ion Binding Sites Within the Hairpin Ribozyme Domains by NMR", Biochemistry, 39, 2174-2182 (2000).
97) P. Schultze, F.W. Smith, N.V. Hud, and J. Feigon: "The Effect of Sodium, Potassium, and Ammonium Ions on the Conformation of the Dimeric Quadruplex formed by the Oxytricha nova Telomere Repeat Oligonucleotide d(G4T4G4)", Nucleic Acids Res., 27, 3018-3028 (1999).
96) A.J. Dingley, J.E. Masse, R.D. Peterson, M. Barfield, J. Feigon, and S. Grzesiek: "Internucleotide Scalar Couplings Across Hydrogen Bonds in Watson-Crick and Hoogsteen Base Pairs of a DNA Triplex", J. Am. Chem. Soc., 121, 6019-6027 (1999).
95) D.E. Gilbert and J. Feigon: "Multi-Stranded DNA Structures", Curr. Opin. Struct. Biol., 9, 305-314 (1999).
94) F.H-T. Allain, Y-M. Yen, J.E. Masse, P. Schultze, T. Dieckmann, R.C. Johnson, and J. Feigon: "Solution Structure of the HMG Protein NHP6A and its Interaction with DNA Reveals the Structural Determinants for Non-Sequence Specific Binding", EMBO J., 18, 2563-2579 (1999).
93) J.E. Masse, F. H-T. Allain, Y-M. Yen, R.C. Johnson, and J. Feigon: "Use of 13C,15N-Labeled DNA in a Sequence Specific Protein-DNA Complex Resolves Ambiguous Assignments of Intermolecular NOEs", J. Am. Chem. Soc., 121, 3547-3548 (1999).
92) V. Sklenár, J. E. Masse, and J. Feigon: "HCCCH Experiment for Through-Bond Correlation of Thymine Resonances in C-13 Labeled DNA Oligonucleotides", J. Magn. Reson.,137, 345-349 (1999).
91) S.E. Butcher, F.H.-T. Allain, and J. Feigon: "Solution Structure of the Loop B Domain From the Hairpin Ribozyme", Nature Struct. Biol., 6, 212-216 (1999).
90) E. Wang and J. Feigon: "Structures of Nucleic Acid Triplexes", in Oxford Handbook of Nucleic Acid Structures (S. Neidle ed.) Oxford University Press, Inc., New York, pp. 355 (1999).
89) N.V. Hud, V. Sklenár , and J. Feigon: "Localization of Ammonium Ions in the Minor Groove of DNA Duplexes in Solution and the Origin of DNA A-Tract Bending", J. Mol. Biol. 286, 651-660 (1999).
88) N.V. Hud, P. Schultze, V. Sklenár, and J. Feigon: "Binding Sites and Dynamics of Ammonium Ions in a Telomere Repeat DNA Quadruplex", J. Mol. Biol. 285, 233-243 (1999).
87) T. Dieckmann, E. Withers-Ward, M.A. Jarosinski, C-F. Liu, I.S.Y. Chen, and J. Feigon: "Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr", Nature Struct. Biol. 5, 1042-1047 (1998).
86) M.R. Wall, T. Dieckmann, J. Feigon, and D. Neuhauser: "Two-Dimensional Filter-Diagonalization: Spectral Inversion of 2D NMR Time-Correlation Signals Including Degeneracies", Chem. Phys. Lett. 291, 465-470 (1998).
85) N.V. Hud, P. Schultze, and J. Feigon: "Ammonium Ion as an NMR Probe for Monovalent Cation Coordination Sites of DNA Quadruplexes", J. Am. Chem. Soc. 120, 6403-6404 (1998).
84) J.E. Masse, P. Bortmann, T. Dieckmann, and J. Feigon: "Simple Efficient Protocol for Enzymatic Synthesis of Uniformly 13C and 15N Labeled DNA for Heteronuclear NMR Studies", Nucleic Acids Research 26, 2618-2624 (1998).
83) J.W. Pang, T. Dieckmann, J. Feigon, and D. Neuhauser: "Extraction of Spectral Information from a Short-time Signal using Filter-Diagonalization: Recent Developments and Applications to Semiclassical Scattering and NMR Signals", J. Chem. Phys. 108, 8360-8368 (1998).
82) C. H. Gotfredsen, P. Schultze, and J. Feigon: "Solution Structure of an Intramolecular PyrimidineoPurineoPyrimidine Triplex Containing an RNA Third Strand", J. Am. Chem. Soc. 120, 4281-4289 (1998).
81) A. K. Phipps, M. Tarköy, P. Schultze, and J. Feigon: "Solution Structure of an Intramolecular DNA Triplex Containing 5-(1-Propynyl)-2’-Deoxyuridine Residues in the Third Strand", Biochemistry 37, 5820-5830 (1998).
80) M. Tarköy, A. K. Phipps, P. Schultze, and J. Feigon: "Solution Structure of an Intramolecular DNA Triplex Linked by Hexakis (ethylene glycol) Units: d(AGAGAGAA-(EG)6-TTCTCTCT-(EG)6-TCTCTCTT)", Biochemistry 37, 5810-5819 (1998).
79) V. Sklenár, T. Dieckmann, S. E. Butcher and J. Feigon: "Optimization of Triple-Resonance HCN Experiments for Application to Larger RNA Oligonucleotides", J. Magn. Reson, 130, 119-124 (1998).
78) S. E. Butcher, T. Dieckmann, and J. Feigon: "Solution Structure of a GAAA Tetraloop Receptor RNA", EMBO J. 16, 7490-7499 (1997).
77) T. Dieckmann, S. E. Butcher, M. Sassanfar, J. W. Szostak and J. Feigon: "Mutant ATP-binding RNA Aptamers Reveal the Structural Basis for Ligand Binding", J. Mol. Biol. 273, 467-478 (1997).
76) O.C. Uhlenbeck, A. Pardi, and J. Feigon: "RNA Structure Comes of Age", Cell 90, 833-840 (1997).
75) T. Dieckmann and J. Feigon: "Assignment Methodology for Larger Oligonucleotides: Application to an ATP-binding RNA Aptamer", J. Biomol. NMR 9, 259-272 (1997).
74) N. V. Hud and J. Feigon: "Localization of Divalent Metal Ions in the Minor Groove of DNA A-tracts", J. Am. Chem. Soc., 119, 5756-5757 (1997).
73) P. Schultze and J. Feigon: "Chirality Errors in Nucleic Acid Structures", Nature 387, 668 (1997).
72) S. E. Butcher, T. Dieckmann and J. Feigon: "Solution Structure of the Conserved 16S-like Ribosomal RNA UGAA Tetraloop", J. Mol. Biol. 268, 348-358 (1997).
71) K. M. Koshlap, P. Schultze, H. Brunar, P. B. Dervan and J. Feigon: "Solution Structure of an Intramolecular DNA Triplex Containing an N7-Glycosylated Guanine Which Mimics a Protonated Cytosine", Biochemistry 36, 2659-2668 (1997).
70) R.D. Peterson and J. Feigon: "Structural Change in Rev Responsive Element RNA of HIV-1 on Binding Rev Peptide", J. Mol. Biol. 264, 863-877 (1996).
69) N. V. Hud, F. W. Smith, F. A. L. Anet, and J. Feigon: "The Selectivity for K+ vs. Na+ in DNA Quadruplexes is Dominated by Relative Free Energies of Hydration: A Thermodynamic Analysis by 1H NMR", Biochemistry 35, 15383-15390 (1996).
68) J. Feigon, T. Dieckmann, and F. W. Smith: "Aptamer Structures from A to z", Chemistry and Biology 3, 611-617 (1996).
67) R. L. Fahrner, T. Dieckmann, S. S. L. Harwig, R. L. Lehrer, D. S. Eisenberg, and J. Feigon: "Solution Structure of Protegrin-1, A Broad-Spectrum Antimicrobial Peptide from Porcine Leukocytes", Chemistry and Biology 3, 543-550 (1996).
66) T. Dieckmann, E. Suzuki, G. K. Nakamura, and J. Feigon: "Solution Structure of an ATP-binding RNA Aptamer Reveals a Novel Fold", RNA 2, 628-640 (1996).
65) J. Feigon: "DNA Triplexes, Quadruplexes, and Aptamers", in Encyclopedia of Nuclear Magnetic Resonance (D. M. Grant and R. K. Harris, eds), John Wiley & Sons Ltd., West Sussex, England, v. 3, pp. 1726-1731 (1996).
64) E. Wang, K. M. Koshlap, P. Gillespie, P. B. Dervan, and J. Feigon: "Solution Structure of a PyrimidineoPurineoPyrimidine Triplex Containing the Sequence Specific Intercalating Non-Natural Base D3", J. Mol. Biol. 257, 1052-1069 (1996).
63) K. J. Addess and J. Feigon: "Introduction to 1H NMR Spectroscopy of DNA", in Bioorganic Chemistry: Nucleic Acids (S. Hecht, ed.), Oxford University Press, New York, pp. 163-185 (1996).
62) V. Sklenár, T. Dieckmann, S. E. Butcher, and J. Feigon: "Through-bond Correlation of Imino and Aromatic Resonances in 13C,15N-labeled RNA via Heteronuclear TOCSY", J. Biomol. NMR 7, 83-87 (1996).
61) J. A. Kelly, J. Feigon and T. O. Yeates: "Reconciliation of the X-ray and NMR Structures of the Thrombin-Binding Aptamer d(GGTTGGTGTGGTTGG)", J. Mol. Biol. 256, 417-422 (1996).
1991-1995
60) F. W. Smith, P. Schultze and J. Feigon: "Solution Structures of Unimolecular Quadruplexes Formed by Oligonucleotides containing Oxytricha Telomere Repeats ", Structure 3, 997-1008 (1995).
59) D. J. Schneider, J. Feigon, Z. Hostomsky and L. Gold: "High Affinity ssDNA Inhibitors of the Reverse Transcriptase of Type 1 Human Immunodeficiency Virus", Biochemistry 34, 9599-9610 (1995).
58) J. Feigon, K. M. Koshlap and F. W. Smith: "1H NMR Spectroscopy of DNA Triplexes and Quadruplexes", in Methods in Enzymology (T. L. James, ed.), Academic Press, vol. 261, pp. 225-255 (1995).
57) K. J. Addess and J. Feigon: "NMR Investigation of Hoogsteen Base Pairing in Quinoxaline Antibiotic-DNA Complexes: Comparison of 2:1 Echinomycin, Triostin A, and [N-MeCys3,N-MeCys7]TANDEM Complexes with DNA Oligonucleotides", Nucl. Acids Res. 22, 5484-5491 (1994).
56) T. Dieckmann and J. Feigon: "Heteronuclear Techniques in NMR Studies of RNA and DNA", Curr. Opinion in Struct. Biol. 4, 745-749 (1994).
55) F. W. Smith, F. W. Lau and J. Feigon: "d(G3T4G3) Forms An Asymmetric Diagonally Looped Dimeric Quadruplex With Guanine 5'-Syn-Syn-Anti And 5'-Syn-Anti-Anti Glycosidic Conformations", Proc. Natl. Acad. Sci. USA 91, 10546-10550 (1994).
54) K. J. Addess and J. Feigon: "Sequence Specificity of Quinoxaline Antibiotics: 2. NMR Studies of the Binding of [N-MeCys3,N-MeCys7]TANDEM and Triostin A to DNA Containing a CpI Step", Biochemistry 33, 12397-12404 (1994).
53) K. J. Addess and J. Feigon: "Sequence Specificity of Quinoxaline Antibiotics: 1. Solution Structure of a 1:1 Complex Between Triostin A and [d(GACGTC)]2 and Comparison with the Solution Structure of the [N-MeCys3,N-MeCys7]TANDEM-[d(GATATC)]2 Complex", Biochemistry 33, 12386-12396 (1994).
52) R. D. Peterson, D. P. Bartel, J. W. Szostak, S. J. Horvath and J. Feigon: "1H NMR Studies of the High-affinity Rev Binding Site of the Rev Responsive Element of HIV-1 mRNA: Base Pairing in the Core Binding Element", Biochemistry 33, 5357-5366 (1994).
51) J. Feigon, F. W. Smith, R. F. Macaya and P. Schultze: "DNA Quadruplexes: From Telomeres to Aptamers", in Structural Biology: The State of the Art. Proceedings of the Eighth Conversation in Biomolecular Stereodynamics, Vol. 2 (M. H. Sarma and R. H. Sarma, eds. ), Adenine Press, New York, pp. 127-136 (1994).
50) P. Schultze, F. W. Smith and J. Feigon: "Refined Solution Structure of the Dimeric Quadruplex formed from the Oxytricha Telomeric DNA Oligonucleotide d(GGGGTTTTGGGG)", Structure 2, 221-233 (1994).
49) V. Sklenár, R. D. Peterson, M. R. Rejante and J. Feigon: "Correlation of Nucleotide Base and Sugar Protons in 15N Labeled HIV RNA Oligonucleotide by 1H-15N HSQC Experiments", J. Biomol. NMR 4, 117-122 (1994).
48) P. Schultze, R. F. Macaya and J. Feigon: "Three-Dimensional Solution Structure of the Thrombin Binding DNA Aptamer d(GGTTGGTGTGGTTGG)", J. Mol. Biol. 235, 1532-1547 (1994).
47) V. Sklenár, R. D. Peterson, M. R. Rejante, E. Wang and J. Feigon: "Two-Dimensional Triple Resonance HCNCH Experiment for Direct Correlation of Ribose H1’ and Base H8,H6 in 13C, 15N Labeled RNA Oligonucleotides", J. Am. Chem. Soc. 115, 12181-12182 (1993).
46) V. Sklenár, R. D. Peterson, M. R. Rejante and J. Feigon: "Two and Three-Dimensional HCN Experiments for Correlating Base and Sugar Resonances in 15N, 13C Labeled RNA Oligonucleotides", J. Biomol. NMR 3, 721-727 (1993).
45) J. Feigon: "A New DNA Quadruplex", Current Biology 3, 611-613 (1993).
44) F. W. Smith and J. Feigon: "Strand Orientation in the DNA Quadruplex formed from the Oxytricha Telomere Repeat Oligonucleotide d(G4T4G4) in Solution", Biochem. 32, 8682-8692 (1993).
43) K. Koshlap, P. Gillespie, P. B. Dervan and J. Feigon: "The Nonnatural Deoxyribonucleoside D3 Incorporated in an Intramolecular DNA Triplex Binds Sequence Specifically by Intercalation", J. Am. Chem. Soc. 115, 7908-7909 (1993).
42) R. F. Macaya, P. Schultze, F. W. Smith, J. A. Roe, and J. Feigon: "Thrombin-Binding DNA Aptamer Forms a Unimolecular Quadruplex Structure in Solution", Proc. Natl. Acad. Sci. USA 90, 3745-3749 (1993).
41) K. J. Addess, J. S. Sinsheimer, and J. Feigon: "Solution Structure of a Complex Between [N-MeCys3, N-MeCys7]TANDEM and [d(GATATC)]2", Biochem. 32, 2498-2508 (1993).
40) D. E. Gilbert and J. Feigon: "Proton NMR Study of the [d(ACGTATACGT)]2-2Echinomycin Complex: Conformational Changes between Echinomycin Binding Sites", Nucl. Acids Res. 20, 2411-2420 (1992).
39) E. Wang, S. Malek, and J. Feigon: "Structure of a G. T. A Triplet in an Intramolecular DNA Triplex", Biochem. 31, 4838-4846 (1992).
38) J. Feigon, V. Sklenár, E. Wang, D. E. Gilbert, R. F. Macaya, and P. Schultze: "1H NMR Spectroscopy of DNA", in DNA Structures: A Volume of Methods in Enzymology (D. M. J. Lilley and J. E. Dahlberg, eds. ), Academic Press, Orlando, FL, 235-253 (1992).
37) R. F. Macaya, E. Wang, P. Schultze, V. Sklenár and J. Feigon: "Proton NMR Assignments and Structural Characterization of an Intramolecular DNA Triplex", J. Mol. Biol. 225, 755-773 (1992).
36) K. J. Addess, D. E. Gilbert and J. Feigon: "Sequence Specificity of Quinoxaline Antibiotics: A Comparison of the Binding of [N-MeCys3], [N-MeCys7] TANDEM and Echinomycin to DNA Studied by Proton NMR Spectroscopy", Proceedings of the Seventh Conversation in Biomolecular Stereodynamics, Vol. 1 (M. H. Sarma and R. H. Sarma, eds. ), Adenine Press, New York, pp. 147-164 (1992).
35) F. W. Smith and J. Feigon: "Quadruplex Structure of Telomeric DNA Oligonucleotides", Nature 356, 164-168 (1992).
34) R. F. Macaya, P. Schultze and J. Feigon: "Sugar Conformations in Intramolecular DNA Triplexes Determined by Coupling Constants Obtained by Automated Simulation of P. COSY Crosspeaks", J. Am. Chem. Soc. 114, 781-783 (1992).
33) K. J. Addess, D. E. Gilbert, R. K. Olsen, and J. Feigon: "Proton NMR Studies of [N-MeCys3, N-MeCys7]TANDEM Binding to DNA Oligonucleotides: Sequence Specific Binding at the TpA Site", Biochem. 31, 339-350 (1992).
32) R.F. Macaya, D. E. Gilbert, S. Malek, J.S. Sinsheimer, and J. Feigon: "Structure and Stability of X. G. C Mismatches in the Third Strand of Intramolecular Triplexes", Science 254, 270-274 (1991).
31) D. E. Gilbert and J. Feigon: "Structural Analysis of Drug-DNA Interactions", Curr. Opin. Struct. Biol. 1, 439-445 (1991).
30) D. E. Gilbert and J. Feigon: "The DNA Sequence at Echinomycin Binding Sites Determines the Structural Changes Induced by Drug Binding: NMR Studies of Echinomycin Binding to [d(ACGTACGT)]2 and [d(TCGATCGA)]2", Biochemistry 30, 2483-2494 (1991).
29) D. J. Ciesla, D. E. Gilbert, and J. Feigon: "Secondary Structure of the Designed Peptide Alpha-1 Determined by Nuclear Magnetic Resonance Spectroscopy", J. Am. Chem. Soc. 113, 3957-3961 (1991).
1986-1990
28) L. Pucek, E. Wang, J. Feigon, Z. Starcuk, and V. Sklenár: "Water Signal Suppression via Self-Refocused Excitation Sequences", J. Mag. Reson. 91, 120-127 (1991).
27) V. Sklenár and J. Feigon: "Simplification of DNA Proton NMR Spectra by HOHAHA Edited 2D NOE Spectroscopy", J. Am. Chem. Soc. 112, 5644-5645 (1990).
26) V. Sklenár and J. Feigon: "Formation of a Stable Triplex from a Single DNA Strand", Nature 345, 836-838 (1990).
25) J. Feigon, P. Rajagopal, and D. Gilbert: "DNA Structures with Hoogsteen Base Pairs", in Frontiers of NMR in Molecular Biology, UCLA Symposia on Molecular & Cellular Biology, New Series, Vol. 109 (D. Live, I. Armitage, & D. Patel, eds.), Alan R. Liss, Inc., New York, 249-258 (1990).
24) J. Feigon, D. E. Gilbert, E. Wang, P. Rajagopal, G. A. van der Marel and J. H. van Boom: "Triplexes, Duplexes, and Homopurine Self-Complexes Formed From Homopurine and Homopyrimidine DNA Oligonucleotides", in Proceedings of the Sixth Conversation in Biomolecular Stereodynamics, Vol. 3 (M. H. Sarma and R. H. Sarma, eds.), Adenine Press, New York, pp. 207-224 (1990).
23) N. Hua, G. A. van der Marel, J. H. van Boom, and J. Feigon: "Non-Contiguous Regions of Z-DNA in a DNA Dodecamer", Nucleic Acids Research 17, 7923-7944 (1989).
22) P. Rajagopal and J. Feigon: "NMR Studies of Triple Strand Formation From the Homopurine:Homopyrimidine Deoxyribonucleotides d(GA)4 and d(TC)4", Biochemistry 28, 7859-7870 (1989).
21) P. Rajagopal and J. Feigon: "Triple Strand Formation in the Homopurine:Homopyrimidine DNA Oligonucleotides d(GA)4 and d(TC)4", Nature 339, 637-640 (1989).
20) D. E. Gilbert, G. A. van der Marel, J. H. van Boom, and J. Feigon: "Unstable Hoogsteen Base Pairs Adjacent to Echinomycin Binding Sites Within a DNA Duplex", Proc. Natl. Acad. Sci. USA 86, 3006-3010 (1989).
19) P. Rajagopal, D. E. Gilbert, G. A. van der Marel, J. H. van Boom and J. Feigon: "Observation of Exchangeable Proton Resonances of DNA in Two-Dimensional NOE Spectra using a Presaturation Pulse: Application to d(CGCGAATTCGCG) and d(CGCGAm6ATTCGCG)", J. Magn. Res. 78, 526-537 (1988).
18) L. R. Ferguson, W. A. Denny and J. Feigon: "‘Petite’ Mutagenesis in Saccharomyces cerevisiae by a Series of 2, 7-Di-Alkyl-Substituted Derivatives of Proflavine With Differing DNA-Binding Properties", Mutation Research 201, 213-218 (1988).
17) M. J. Ellison, J. Feigon, R. J. Kelleher III, J. F. Habener, A. H. -J. Wang, and A. Rich: "An Assessment of the Z-DNA Forming Potential of d(AT)," Biochemistry 25, 3648-3655 (1986).
Pre-1985
16) G. S. Harbison, J. Feigon, D. J. Ruben, J. Herzfeld, and R. G. Griffin: "Diagonal Peak Suppression in 2D-NOE Spectra," J. Amer. Chem. Soc. 107, 5567-5569 (1985).
15) J. Feigon, A. H. -J. Wang, G. A. van der Marel, J. H. van Boom, and A. Rich: "Z-DNA Forms in Solution without an Alternating Purine-Pyrimidine Sequence," Science 230, 82-84 (1985).
14) W. Leupin, J. Feigon, W. A. Denny, and D. R. Kearns: "Substituent Effects on the Binding of Ethidium and Its Derivatives to Natural DNA," J. Biophys. Chem. 22, 294-303 (1985).
13) J. Feigon, A. H. -J. Wang, G. A. van der Marel, J. H. van Boom, and A. Rich: "A One- and Two-Dimensional NMR Study of the B to Z Transition of (m5dC-dG)3 in Methanolic Solution," Nucl. Acids Res. 12, 1243-1263 (1984).
12) J. Feigon, W. A. Denny, W. Leupin, and D. R. Kearns: "The Interactions of Antitumor Drugs with Natural DNA: A 1H NMR Study of Binding Mode and Kinetics," J. Medicinal Chemistry 27, 450-465 (1984).
11) J. Feigon, W. Leupin, W. A. Denny, and D. R. Kearns: "A Two-Dimensional Proton Nuclear Magnetic Resonance Investigation of the Synthetic Deoxyribonucleic Acid Decamer d(ATATCGATAT)," Biochemistry 22, 5843-5951 (1983).
10) J. Feigon, W. A. Denny, W. Leupin, and D. R. Kearns: "Proton Nuclear Magnetic Resonance Investigation of the Conformation and Dynamics in the Synthetic Deoxyribonucleic Acid Decamers, d(ATATCGATAT) and d(ATATGCATAT)," Biochemistry 22, 5930-5942 (1983).
9) J. Feigon, J. M. Wright, W. A. Denny, W. Leupin, and D. R. Kearns: "Application of Multiple Pulse 1H NMR Techniques to the Study of Two Synthetic DNA Decamers," in Cold Spring Harbor Symposia on Quantitative Biology, Vol. XLVII, 207-217 (1983).
8) J. Feigon, J. M. Wright, W. A. Denny, W. Leupin, and D. R. Kearns: "Use of Two-Dimensional NMR in the Study of a Double-Stranded DNA Decamer,", J. Am. Chem. Soc. 104, 5540-5541 (1982).
7) J. Feigon, W. Leupin, W. A. Denny, and D. R. Kearns: "Binding of Ethidium Derivatives to Natural DNA: A 300 MHz 1H NMR Study," Nucl. Acids Res. 10, 749-762 (1982).
6) J. Granot, J. Feigon, and D. R. Kearns: "Interactions of DNA with Divalent Metal Ions. 31P NMR Studies," Biopolymers 21, 181-201 (1982).
5) J. M. Wright, J. Feigon, W. A. Denny, W. Leupin, and D. R. Kearns: "Use of the Time-Shared Redfield 214 Pulse Method to Measure Relaxation Rates of Imino Protons of a Double Stranded DNA Decamer in Water," J. Magn. Reson. 45, 514-519 (1981).
4) D. R. Kearns, N. Assa-Munt, R. W. Behling, T. A. Early, J. Feigon, J. Granot, W. Hillen, and R. D. Wells: "NMR Relaxation Studies of the Structural and Dynamic Properties of DNA," in Biomolecular Stereodynamics, Vol. I, ed. R. H. Sarma, Adenine Press, New York, 345-366 (1981).
3) T. A. Early, J. Feigon, and D. R. Kearns: "Direct Measurement of Spin-Spin and Spin-Lattice Relaxation Rates of Exchangeable N-H Protons of DNA in Water," J. Magn. Reson. 41, 343-348 (1980).
2) J. Feigon and D. R. Kearns: "1H NMR Investigation of the Conformational States of DNA in Nucleosome Core Particles", Nucl. Acids Res. 6, 2327-2337 (1979).
1) F. P. De Haan, W. D. Covey, G. L. Decker, N. J. Baker, J. F. Feigon, K. D. Miller, and E. D. Stetler: "On the Mechanism of Friedel-Crafts Acylation and Sulfonation Reactions", J. Amer. Chem. Soc. 101, 1336-1337 (1979).