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Nucleolin RBD12 |
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F. H.-T. Allain, D.E. Gilbert, P. Bouvet, and J. Feigon: "Solution structure of the two N-terminal RNA-binding domains of nucleolin and NMR study of the interaction with its RNA target", J. Mol. Biol. 303, 227-241 (2000). [abstract]
Ribbon representation of RBD12. Since the linker region (green) is flexible and no NOEs are observed between the two RBDs, the orientation of the two RBDs relative to one another is not defined in solution. The structure shown has the two RBDs oriented in such a way that their b-strands can interact with the RNA. Side-chains of F17, Y58, L103, and Y140 shown on the structure have intermolecular NOEs to the RNA loop nucleotides. |
