Comparison of NHP6A and LEF1

F.H-T. Allain, Y-M. Yen, J.E. Masse, P. Schultze, T. Dieckmann, R.C. Johnson, and J. Feigon: "Solution structure of the HMG protein NHP6A and its interaction with DNA reveals the structural determinants for non-sequence specific binding",  EMBO J. 18, 2563-2579 (1999). [abstract]

PDB code: 1CG7

Comparison between the NHP6A-DNA^sry NMR- based model (left) and the LEF1- DNA structure (right) (Love et al., 1995). (A) View of the two complexes with the two proteins oriented similarly. (B) View of the two complexes with their DNA oriented similarly. The DNA is gray except for the TTG sequence which is highlighted in cyan (T) and green (G). The non- helical N- and C-terminal residues are shown in blue and red, respectively.