Dyskeratosis Congenita Mutation

in Telomerase RNA

C.A. Theimer, L.D, Finger, and J. Feigon: “YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA”, RNA, 9,1446-1455 (2003). [abstract]

PDB Code: 1Q75

Stereoview of the lowest energy structure of the DCloop hairpin, with a major groove view of the pentaloop and hydrogen bonds for the U105-G108 base pair indicated by black dashed lines.