NHP6A Bound to Cisplatin-Modified DNA

B. Wong, J.E. Masse,  Y-M. Yen, P. Giannikoupolous, J. Feigon, and R.C. Johnson: "Binding of Cisplatin-Modified DNA by  Saccharomyces cerevisiae HMGB Protein NHP6A", Biochemistry 41, 5404-5414 (2002). [abstract]

Schematic representation of two modes of binding by NHP6A to cisplatin-modified DNA. Surface representation of NHP6A is shown bound in either orientation to the cisplatin-modified 19 bp DNA sequence.