UCLA Department of Chemistry & Biochemistry

TORRES LAB


Publications

2019

Gholkar A.A., Schmollinger S., Velasquez E.F., Lo Y.C., Cohn W., Capri J., Dharmarajan H., Deardorff W.J., Gao L.W., Abdusamad M. Whitelegge J.P., and Torres J.Z. “Regulation of Iron Homeostasis Through Parkin-mediated Lactoferrin Ubiquitylation”, 2019 Under Review.

Sawicki M.P., Gholkar A.A., and Torres J.Z. “Menin Associates with the Mitotic Spindle and is Important for Cell Division”, Endocrinology 2019 Under Revision.

Xia X., Lo Y.C., Gholkar A.A., Senese S., Ong Y.Y., Velasquez E.F., Damoiseaux R., and Torres J.Z. “Leukemia Cell Cycle Chemical Profiling Identifies the G2-Phase Leukemia Specific Inhibitor Leusin-1” , ACS Chemical Biology 2019, May 2. doi: 10.1021/acschembio.9b00173. PMID:31046221)

Ong J.Y. and Torres J.Z. “Dissecting the Mechanisms of Cell Division”, Journal of Biological Chemistry 2019. (Commissioned Review)

Lo Y.C. and Torres J.Z. “In Silico Repurposing of Cell Cycle Modulators for Cancer Treatment” , In Silico Drug Design: Repurposing Techniques and Methodologies, 2019 April. 1, Ch.9, Print ISBN 9780128161258. In Press (Book Chapter)

Ong J.Y. and Torres J.Z. “E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting” , The Ubiquitin/Proteasome System, 2019 Print ISBN 978-953-51-7766-1. In Press (Book Chapter)

2018

Ünal E. and Torres J.Z. “Ensuring Fidelity of Chromosome Segregation”, Molecular Biology of the Cell 2018 Mar 15;29(6):687. doi: 10.1091/mbc. E17-11-0673. PMID:29535171 (Meeting Review)

2017

Lacks D.R., Oses-Prieto J.A., Alvarado A.G., Nakashima J., Chand S., Azzam D.B., Gholkar A.A., Sperry J., Ludwig K., Condro M.C., Nazarian S., Cardenas A., Shih M.Y.S., Damoiseaux R., France B., Orozco N., Visnyei K., Crisman T. J., Gao F., Torres J.Z., Coppola G., Burlingame A.L., and Kornblum H.I., “A Molecular Cascade Modulates MAP1B and Confers Resistance to mTOR Inhibition in Human Glioblastoma”, Neuro Oncology 2017 Nov 9. doi: 10.1093/neuonc/nox215. PMID:29136244

Senese S., Lo Y.C., Gholkar A.A., Li C.M., Huang Y., Mottahedeh J., Kornblum H.I., Damoiseaux R., and Torres J.Z. “Microtubins: a Novel Class of Small Synthetic Microtubule Targeting Drugs that Inhibit Cancer Cell Proliferation”, Oncotarget 2017 Oct 19;8(61):104007-104021. doi: 10.18632/oncotarget.21945. eCollection 2017 Nov 28. PMID:29262617

Lo Y.C., Senese S., France B., Gholkar A.A., Damoiseaux R., and Torres J.Z. “Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential”, Scientific Reports 2017 Sep 12;7(1):11261. doi: 10.1038/s41598-017-11508-2. PMID:28900159

Fernández-Del-Río L., Nag A., Gutiérrez Casado, E., Ariza, J., Awad A.M., Joseph A.I., Kwon O., Verdin E., de Cabo R., Schneider C., Torres J.Z., Burón M.I., Clarke C.F., and Villalba J.M., “Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor”, Free Radical Biology & Medicine 2017 Jun 8. pii: S0891-5849(17)30629-9. doi: 10.1016/j.freeradbiomed.2017.06.006. PMID:28603085

Chan A.H., Yi S.W., Weiner E.M., Amer B.R., Sue C.K., Wereszczynski J., Dillen C.A., Senese S., Torres J.Z., McCammon J., Miller L.S., Jung M.E., and Clubb R.T. “NMR Structure-Based Optimization of Staphylococcus aureus Sortase A Pyridazinone Inhibitors”, Chemical Biology & Drug Design 2017 Feb. 3., doi: 10.1111/cbdd.12962 PMID:28160417

2016

Bradley M., Ramirez I., Cheung K., Gholkar A.A., and Torres J.Z. “Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks”, Journal of Visualized Experiments 2016 Dec. 24, (118):1-9, e54870, doi:10.3791/54870. PMID:28060263

Lo Y.C., Gui R., Honda H., and Torres J.Z. “Quantitative Methods in System-based Drug Discovery”, Complex Systems, Sustainability and Innovation, 2016 Dec. 14, Ch.5, pgs.85-98, DOI 53186, ISBN 978-953-51-2842-7, Print ISBN ISBN 978-953-51-2841-0. (Book Chapter)

Lo Y.C., Gui R., Honda H., and Torres J.Z. “Computer-Aided Biosensor Design”, Computer-aided Technologies –Applications in Engineering and Medicine, 2016 Dec. 7, Ch.6, pgs. 121-135, DOI 52192, ISBN 978-953-51-2788-8, Print ISBN 978-953-51-2787-1. (Book Chapter)

Lo Y.C. and Torres J.Z. “Chemical Similarity Networks for Drug Discovery”, Special Topics in Drug Discovery, 2016 Nov. 30, Ch.3, pgs. 53-72, DOI 52373, ISBN 978-953-51-2800-7, Print ISBN 978-953-51-2799-4. (Book Chapter)

Gholkar A.A., Cheung K., Williams K.J., Lo Y.C., Hamideh S.A., Nnebe C., Khuu C., Bensinger S.J. and Torres J.Z. “Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division”, Journal of Biological Chemistry 2016 Aug 12;291(33):17001-8. doi: 10.1074/jbc.C116.737346. PMID:27378817

Lo Y.C., Senese S., Damoiseaux R., and Torres J.Z. “3D Chemical Similarity Networks for Structure-Based Target Prediction and Scaffold Hopping”, ACS Chemical Biology 2016 Aug 19;11(8):2244-53. doi: 10.1021/acschembio.6b00253. PMID:27285961

Soh H., Venkatesan N., Veena M.S., Ravichandran S., Zinabadi A., Basak S.K., Parvatiyar K., Srivastava M., Liang L.J., Gjertson D.W., Torres J. Z., Moatamed N.A., and Srivatsan E.S. “Cystatin E/M suppresses tumor cell growth through cytoplasmic retention of NF-κB”, Molecular and Cellular Biology 2016 May 31;36(12):1776-92. doi: 10.1128/MCB.00878-15. PMID:27090639

Cheung K., Senese S., Kuang J., Bui N., Ongpipattanakul C., Gholkar A., Cohn W., Capri J., Whitelegge J.P., and Torres J.Z. “Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing”, Molecular & Cellular Proteomics 2016 May;15(5):1658-69. doi:10.1074/mcp.M115.056465. Epub 2016 Feb 29. PMID:26929214

Gholkar A.A., Senese S., Lo Y.C., Vides E., Contreras E., Hodara E., Capri J., Whitelegge J.P., and Torres J.Z. “The X-linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division”, Cell Reports 2016 Jan 12;14(2):180-188. doi: 10.1016/j.celrep.2015.12.035. Epub 2015 Dec 31. PMID:26748699

2015

McNamara D.E., Senese S., Yeates T.O., and Torres J.Z. “Structures of potent anticancer compounds bound to tubulin”, Protein Science 2015 Jul;24(7):1164-1172. doi: 10.1002/pro.2704. Epub 2015 May 27. PMID:25970265.

Xia X., Gholkar A., Senese S., and Torres J.Z. “A LCMT1-PME1 Methylation Equilibrium Controls Mitotic Spindle Size”, Cell Cycle 2015 Jun.18;14(12):1938-1947. PMID:25839665.

Gholkar A.A., Senese S., Lo Y.C., Capri J., Deardorff W.J., Dharmarajan H., Contreras E., Hodara E., Whitelegge J.P., Jackson P.K. and Torres J.Z. "Tctex1d2 Associates with Short-Rib Polydactyly Syndrome Proteins and is Required for Ciliogenesis". Cell Cycle 2015 Apr 3;14(7):1116-1125. PMID:25830415.

Lo Y.C., Senese S., Li C., Huang Y., Damoiseaux R., and Torres J.Z. "Large-scale Chemical Similarity Networks for Target Profiling of Compounds Identified in Cell-based Chemical Screens". PLOS Computational Biology 2015 Mar 31;11(3):e1004153. doi: 10.1371/journal.pcbi.1004153. eCollection 2015 Mar. PMID:25826798.

Senese S., Cheung K., Lo Y.C., Gholkar A., Xia X., Wohlschlegel J., and Torres J.Z. "A Unique Insertion in STARD9's Motor Domain Regulates Its Stability". Molecular Biology of the Cell 2015 Feb 1;26(3):440-52. doi: 10.1091/mbc.E14-03-0829. Epub 2014 Dec 10.2014. PMID: 25501367.

2014

Veena M.S., Wilken R., Zheng J., Gholkar A, Venkatesan N, Vira D., Ahmed S., Basak S.K., Delgard C.L., Ravichandran S, Batra R. K., Kasahara N., Elashoff D., Fishbein M.C., Whitelegge J.P., Torres J.Z., Wang M.B., and Srivatsan E.S. "p16 and gigaxonin are associated with the ubiquitination of NFkB in cisplatin induced senescence of cancer cells". Journal of Biological Chemistry 2014 Oct 20. pii: jbc.M114.568543. PMCID: PMC4263890.

Senese S., Lo Y.C., Huang D., Zangle T.A., Gholkar A.A., Robert L., Homet B., Ribas A., Summers M.K., Teitell M.A., Damoiseaux R. and Torres J.Z. "Chemical Dissection of the Cell Cycle: Probes for Cell Biology and Anti-cancer Drug Development". Cell Death & Disease 2014 Oct 16;5:e1462. doi:10.1038/cddis.2014.420. PMID:25321469.

Sakkiah S., Senese S., Yang Q., Lee K., and Torres J.Z. "Dynamic and Multi-pharmacophore Modeling for Designing Polo-box Domain Inhibitors". Plos One 2014 Jul 18, 9(7):e101405. PMCID: PMC4103762.

Sakkiah, S., Arooj M., Lee K., and Torres J.Z. “Theoretical Approaches to Identify the Potent Scaffold for Human Sirtuin 1 Activator: Bayesian Modeling and Density Functional Theory”. Medicinal Chemistry Research 2014 March 09, 23(5) 2161-2700.

2013

Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. “An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity”. Cancer Research 2013 Apr 22;73:2850-2862. PMCID:PMCID:PMC3919498.

2012

Torres, J.Z., “STARD9 is a novel mitotic kinesin and antimitotic target”. BioArchitecture 2012 Jan 1;2(1):19-22. PMCID: PMC3383713.

2011

Torres J.Z., Summers M.K., Peterson D., Brauer M.J., Lee J., Senese S., Gholkar A.A., Lo Y., Lei X., Jung K., Anderson D.C., Davis D.P., Belmont L., and Jackson P.K. “The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly”. Cell 2011, Dec;9(6):1309-1323.

Prior to UCLA

Torres J.Z., Ban K.H., and Jackson P.K. “A specific form of PPP2 regulates APC/C association with spindle poles”. Molecular Biology of the Cell. 2010 Mar;21(6):897-904.;21 897-904.

Torres J.Z., Miller J.J. and Jackson P.K. “High throughput generation of tagged stable cell lines for proteomic analysis”. Proteomics 2009 May;9(10):2888-2891.

Ban K.H., Torres J.Z., Miller J.J., Mikhailov A., Nachury M.V., Tung J.J., Reider C.L. and Jackson P.K. “The END network couples spindle pole assembly to inhibition of the Anaphase Promoting Complex/Cyclosome in early mitosis”. Dev. Cell. 2007 Jul;13(1):29-42.

Azvolinsky A, Dunaway S., Torres J.Z., Bessler B., and Zakian V.A. “The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes”. Genes Dev. 2006 Nov 15;20(22):3104-16.

Torres J.Z., Schnakenberg S.L. and Zakian V.A. “The Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra S phase checkpoint and fork restart activities”. Mol Cell Biol. 2004 Apr;24(8):3198-212.

Torres J.Z., Bessler J.B., and Zakian V.A. “Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p”. Genes Dev. 2004 Mar 1;18(5):498-503.

Bessler J.B., Torres J.Z., and Zakian V.A. “The Pif1p subfamily of helicases: region-specific DNA helicases?”. Trends in Cell Biology. 2001 Feb;11(2):60-65.

 


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