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| Structural Biology & Bioinformatics | Map of UCLA | Useful Information | Instrumentation Center |
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James
U. Bowie
Professor Membrane protein structure and folding; polymerizing protein modules for the construction of large macromolecular structures |
Office
- (310) 206-4747 |
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Guillaume
Chanfreau
Associate Professor RNA processing and metabolism in eukaryotes; RNA-Protein interactions; RNA endonucleases |
Office
- (310) 825-4399 |
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Catherine
F. Clarke |
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Steven
G. Clarke |
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Robert
T. Clubb
Associate Professor Mechanisms of bacterial pathogenesis; Function of cell surface virulence factors in Staphylococcus aureus and Bacillus anthracis; Heteronuclear multidimensional NMR spectroscopy; Mechanisms of recombination |
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Albert
J. Courey
Professor Transcriptional regulation; biochemical and molecular genetic analysis of pattern formation during fruit fly embryogenesis |
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David
S. Eisenberg
Professor Study of biochemical macromolecules by X-ray diffraction and computational methods; structure and action of enzymes and of membrane-related proteins; protein folding and the atomic basis of biological recognition National Academy of Sciences Member |
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Juli
Feigon
Professor Conformational studies of nucleic acids using multidimensional NMR techniques: DNA triplexes and quadruplexes; drug-DNA complexes, DNA and RNA aptamers; DNA and RNA-protein complexes
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Office
- (310) 206-6922
Lab - (310) 825-9232 Fax - (310) 825-0982 256 Boyer Hall feigon@mbi.ucla.edu |
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James
W. Gober
Professor Transcriptional regulation during cell differentiation in Caulobacter; genetics and biochemistry of cell cycle and polar gene expression; DNA higher-order structure and transcriptional activation; chromosome structure |
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Jay
D. Gralla
Professor The role of nucleic acid-protein complexes in cellular controls; repression and activation of transcription; mechanism of action of anti-cancer drugs that attack DNA; chemical probes of DNA structure
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Office
- (310) 825-1620 |
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Wayne
L. Hubbell
Professor Molecular mechanisms of membrane transduction and switching processes, primarily visual transduction and voltage dependent membrane gating systems. Development of spectroscopic approaches for the study of membrane structure, dynamics and electrostatic phenomena National Academy of Sciences Member |
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Carla
M. Koehler
Associate Professor Genetic and biochemical studies of protein import into mitochondria, role of mitochondrial biogenesis in cellular functions and disease
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Office
- (310) 794-4834 |
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Christopher
J. Lee
Professor Bioinformatics and genomics: genome sequence analysis; computational methods for identification of single nucleotide polymorphisms; genomics databases; prediction of protein structure and function |
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Joseph
A. Loo
Professor Development of novel bioanalytical methods for the characterization of proteins and their post-translational modifications and their application for drug discovery and proteomics. Development and application of electrospray ionization mass spectrometry for the study of noncovalently-bound macromolecular complexes and their interactions with inhibitors. Fundamentals of analytical chemistry and mass spectrometry. |
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Parag Mallick Adjunct Assistant Professor Our group primarily develops and applies systems approaches to quantitatively describe organisms' physiologic states. Applications include enabling personalized, predictive medicine. Specifically, we are developing experimental techniques and computational methods for quantitative proteomic profiling and pattern discovery. In addition, we are developing tools to integrate genomic information with proteomic information so as to better elucidate the genome and to develop more detailed models of regulation. |
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Harold
G. Martinson
Professor Coupling of RNA processing with transcription in eukaryotes: splicing; cleavage & polyadenylation; poly(A)-dependent pausing and termination. |
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Sabeeha
Merchant
Professor Copper and iron homeostasis; re-modelling of the photosynthetic apparatus in iron-deficiency; mechanisms of copper sensing and signal transduction; cytochrome c biogenesis; chloroplast metabolism; photosynthesis |
Office
- (310) 825-8300 |
| Margot Quinlan Assistant Professor -- joining the department in July 2008! Dynamics of the actin cytoskeleton; the role of Spire and Cappuccino in regulating actin and oogenesis; biochemistry, genetics and microscopy |
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Emil
Reisler
Professor Structure and function of contractile proteins; protein-protein and protein-ligand interactions; mechanism of muscle contraction; mechanism of ATP hydrolysis; self assembly of myosin and actin |
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Joan
S. Valentine
Professor Bioinorganic chemistry study of the reactivity and other properties of transition metal complexes that are analogues of metalloenzyme active sites; study of structure-function relationships in the enzyme copper-zinc superoxide dismutase using site-directed utagenesis; biochemistry of oxygen, superoxide, and peroxide National Academy of Sciences Member Editor-in-Chief, Accounts of Chemical Research |
Office
- (310) 825-9835 |
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Richard
L. Weiss
Professor Compartmentation of enzymes and metabolites; molecular genetics, metabolic and genetic regulation in eukaryotic microorganisms |
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Todd
O. Yeates |
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Emeriti
Faculty
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Daniel
E. Atkinson
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Office
- (310) 825-1159 |
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Paul
D. Boyer |
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Richard E. Dickerson
Professor Emeritus X-ray studies of nucleic acids and proteins; sequence/structure relationships in double-helical DNA; binding of anti-tumor drugs and recognition proteins to DNA; evolution of macromolecules and metabolic pathways National Academy of Sciences Member |
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Verne
N. Schumaker
Professor Emeritus Surface architecture of serum lipoproteins using monoconal antibodies, and the structure of the gene coding for apolipoprotein B; mechanism of activation of the first component of complement, and the role of segmental flexibility in the immune system; expression of complement proteins |
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Charles
A. West
Professor Emeritus Plant biochemistry; regulation of the biosynthesis of isoprenoid compounds with physiological activity including disease resistance agents and the gibberellin family of growth regulators; diterpene metabolism, studies of molecular mechanisms involved in plant disease resistance |
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updated 04/17/07