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Steven Clarke Lab Publications - 2008 - 2011

251. Lissina, E., Young, B., Urbanus, M. L., Guan, X. L., Lowenson, J., Hoon, S., Baryshnikova, A., Riezman, I., Michaut, M., Riezman, H., Cowen, Leah E., Wenk, M., Clarke, S. G., Giaever, G., and Nislow, C. (2011) "A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis" PLoS Genetics, 7, 1-16.

250. Adler, L. N., Gomez, T. A., Clarke, S. G., and Linster, C. L. (2011) "A Novel GDP-D-glucose Phosphorylase Involved in Quality Control of the Nucleoside Diphosphate Sugar Pool in Caenorhabditis elegans and Mammals" J. Biol. Chem. 286, 24, 21511–21523.

249. Khare, S., Linster, C. L., and Clarke, S. G. (2011) "The Interplay between Protein L-Isoaspartyl Methyltransferase Activity and Insulin-Like Signaling to Extend Lifespan in Caenorhabditis elegans" PLos One, 6, 1-12.

248. Webb., K. J., Al-Hadid, Q., Zurita-Lopez, C. I., Young, B. D., Lipson, R. S., and Clarke, S. G. (2011) "The Ribosomal L1 Protuberance in Yeast Is Methylated on a Lysine Residue Catalyzed by a Seven-β-strand Methyltransferase" J. Biol. Chem. 286, 21, 18405–18413.

247. Rust, H. L., Zurita-Lopez. C. I., Clarke, S. G., Thompson, P.R. (2011) "Mechanistic Studies on Transcriptional Coactivator Protein Arginine Methyltransferase 1" Biochemistry 50, 3332–3345.

246. Butler, J. S., Zurita-Lopez, C. I., Clarke, S. G., Bedford, M. T., Dent, S. Y. R. (2011) "Protein-arginine Methyltransferase 1 (PRMT1) Methylates Ash2L, a Shared Component of Mammalian Histone H3K4 Methyltransferase Complexes" J. Biol. Chem. 286, 14, 12234–12244.

245. Petrossian, T. C., and Clarke, S. G. (2011) "Uncovering the Human Methyltransferasome" Molecular & Cellular Proteomics 10.1, 1-12.

244. Webb, K. J., Zurita-Lopez, C. I., Al-Hadid, Q., Laganowsky, A., Young, B. D., Lipson, R. S., Souda, P., Faull, K. F., Whitelegge, J. P., and Clarke, S. G. (2010) "A Novel 3-Methylhistidine Modification of Yeast Ribosomal Protein Rpl3 Is Dependent upon the YIL110W Methyltransferase" J. Biol. Chem. 285, 48, 37598–37606.

243. Chen, T., Nayak, N., Majee, S. M., Lowenson, J., Schafermeyer, K. R., Eliopoulos, A. C., Lloyd, T. C., Dinkins, R., Perry, S., Forsthoefel, N. R., Clarke, S. G., Vernon, D. M., Zhou, Z. S., Rejtar, T., and Downie, A. B. (2010) "Substrates of the Arabidopsis thaliana Protein Isoaspartyl Methyltransferase 1 Identified Using Phage Display and Biopanning" J. Biol. Chem. 285, 48, 37281–37292.

242. Lipson, R. S., Webb, K. J., and Clarke, S. G. (2010) "Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae" Archives of Biochemistry and Biophysics 500, 137-143.

241. Vinci, C. R., and Clarke, S. G. (2010) "Homocysteine Methyltransferases Mht1 and Sam4 Prevent the Accumulation of Age-damaged (R,S)-AdoMet in the Yeast Saccharomyces cerevisiae" J. Biol. Chem. 285, 27, 20526–20531.

240. Webb, K. J., Lipson, R. S., Al-Hadid, Q., Whitelegge, J. P., and Clarke, S. G. (2010) "Identification of Protein N-Terminal Methyltransferases in Yeast and Humans" Biochemistry, 49, 25, 5225–5235.

239. Fisk, J. C., Zurita-Lopez, C., Sayegh, J., Tomasello, D. T., Clarke, S. G., and Read, L. K. (2010) "TbPRMT6 Is a Type I Protein Arginine Methyltransferase That Contributes to Cytokinesis in Trypanosoma brucei" Eukaryotic Cell, Volume 9., No. 6, 866-877.

238. Vinci, C.R. and Clarke, S.G. (2010) "Yeast, Plants, Worms, and Flies Use a Methyltransferase to Metabolize Age-Damaged (R,S)-AdoMet, but What Do Mammals Do?" Rejuvenation Research,
Volume 13, Number 2-3, 362-364.

237. Lipson, R. S., Webb, K. J., and Clarke, S. G. (2010) "Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae" Biochemical and Biophysical Research Communications 391, 1658–1662.

236. Lakowski, T.M, Zurita-Lopez, C., Clarke, S.G., and Frankel, A. (2010) "Approaches to measuring the activities of protein arginine N-methyltransferases" Analytical Biochemistry 397, 1-11.

235. Petrossian, T. C., and Clarke, S. G. (2009) “Bioinformatic Identification of Novel Methyltransferases” Epigenomics 1, 163-175.

Poster Presentation: Petrossian, T. C. and Clarke, S. G. (2009) "Computational methods to identify novel methyltransferases" BMC Bioinformatics 10 (Suppl. 13) 7-8.

234. Khare, S., Gomez, T. A., Linster, C. L. and Clarke, S. G. (2009) “Defective Responses to Oxidative Stress in Protein L-Isoaspartyl Repair-Deficient Caenorhabditis elegans” Mechan. Ageing Develop. 130, 670-680.

233. Petrossian, T. C., and Clarke, S. G. (2009) “Multiple Motif Scanning to Identify Methyltransferases from the Yeast Proteome” Mol. Cell. Proteomics 8, 1516-1526.

232. Fisk, J. C., Sayegh, J., Zurita-Lopez, C., Menon, S., Presnyak, V., Clarke, S. G., and Read, L. K. (2009) “A Type III Protein Arginine Methyltransferase from the Protozoan Parasite, Trypanosoma brucei” J. Biol. Chem. 284, 11590-11600.

231. Bedford, M. T., and Clarke, S. G. (2009) “Protein Arginine Methylation in Mammals: Who, What and Why” Mol. Cell 33, 1-13.

230. Webb, K. J., Laganowsky, A., Whitelegge, J. P., and Clarke, S. G. (2008) “Identification of Two SET-Domain Proteins Required for Methylation of Lysine Residues in Yeast Ribosomal Protein Rpl42ab” J. Biol. Chem. 283, 35561-35568.

229. Gomez, T. A., Banfield, K. L., and Clarke, S. G. (2008) “The Protein L-Isoaspartyl-O-Methyltransferase Functions in the Caenorhabditis elegans Stress Response” Mechan. Ageing Develop. 129, 752-758.

228. Linster, C. L., and Clarke, S. G. (2008) “L-Ascorbate Biosynthesis in Higher Plants: Role of VTC2” Trends Plant Sci. 13, 567-573. (Article featured as a cover illustration). PMCID:

227. Banfield, K. L., Gomez, T. A., Lee, W., Clarke, S., and Larsen, P. L.(2008) “Protein-Repair and Hormone-Signaling Pathways Specify Dauer and Adult Longevity and Dauer Development in Caenorhabditis elegans” J. Gerontol. A. Biol. Sci. Med. Sci. 63A, 798-808.

226. Sayegh, J., and Clarke, S. (2008) "Hsl7 is a Substrate-specific Type II Protein Arginine Methyltransferase in Yeast" Biochem. Biophys. Res. Commun. 372, 811-815.

225. Linster, C. L., Adler, L. N., Webb, K., Christensen, K. C., Brenner, C., and Clarke, S. G. (2008) "A Second GDP-l-Galactose Phosphorylase in Arabidopsis en Route to Vitamin C: Covalent Intermediate and Substrate Requirements for the Conserved Reaction" J. Biol. Chem. 283, 18483-18492.

224. Alfaro, J. F., Gillies, L. A., Sun, H. G., Dai, S., Zang, T., Klaene, J. J., Kim, B. J., Lowenson, J. D., Clarke, S. G., Karger, B. L., and Zhou, Z. S. (2008) "Chemo-Enzymatic Detection of Protein Isoaspartate Using Protein Isoaspartate Methyltransferase and Hydrazine Trapping" Anal. Chem. 80, 3882-3889.

223. Dumlao, D. S., Hertz, N., and Clarke, S. (2008) "Secreted “3-Isopropylmalate Methyl Ester Signals Invasive Growth During Amino Acid Starvation in Saccharomyces cerevisiae” Biochemistry, 47 (2), 698 -709, 2008.