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Steven Clarke Lab Publications - 2000 - 2003

183. Kalhor, H. R., and Clarke, S. (2003) "Novel Methyltransferase for Modified Uridine Residues at the Wobble Position of tRNA" Mol. Cell Biol. 23, 9283- 9292.

182. Katz, J. E., Dlakic, M., and Clarke, S. (2003) "Automated Identification of Putative Methyltransferases from Genomic Open Reading Frames" Mol. Cell. Proteomics 2, 525-540.

181. Clarke, S. (2003) "Aging as War Between Chemical and Biochemical Processes: Protein Methylation and the Recognition of Age-Damaged Proteins for Repair" Ageing Res. Rev. 2, 263-285.

180. Mura, C., Katz, J. E., Clarke, S. G., and Eisenberg, D. (2003) "Structure and Function of an Archaeal Homolog of Survival Protein E (SurE): An Acid Phosphatase with Purine Nucleotide Specificity" J. Mol. Biol. 326, 1559-1575.

179. Farrar, C., and Clarke, S. (2002) "Altered Levels of S-Adenosylmethionine and S-Adenosylhomocysteine in the Brains of L-Isoaspartyl (D-Aspartyl) O-Methyltransferase-deficient Mice" J. Biol. Chem. 277, 27856-27863.

178. Clarke, S., and Banfield, K. (2002) "Can Elevated Plasma Homocysteine Levels Result in the Inhibition of Intracellular Methyltransferases" in Chemistry and Biology of Pteridines and Folates (Milstein, S., Kapatos, G., Levine, R. A., and Shane, B., eds), pp. 557-562, Kluwer Academic Publishers, Boston.

177. Ryttersgaard, C., Griffith, S. C., Sawaya, M. R., MacLaren, D. C., Clarke, S., and Yeates, T. O. (2002) "Crystal structure of human L-isoaspartyl methyltransferase" J. Biol. Chem. 277, 10642-10646.

176. Clarke, S. (2002) "Commentary: The Methylator Meets the Terminator" Proc. Natl. Acad. Sci. U. S. A. 99, 1104-1106.

175. Frankel, A., Yadav, N., Lee, J., Branscombe, T. L., Clarke, S., and Bedford, M. T. (2002) "The Novel Human Protein Arginine N-Methyltransferase PRMT6 is a Nuclear Enzyme Displaying Unique Substrate Specificity" J. Biol. Chem. 277, 3537-3543.

174. Thapar, N., Griffith, S., Yeates, T. O., and Clarke, S. (2002)."Protein Repair Methyltransferase from the Hyperthermophilic Archaeon Pyrococcus furiosus: Unusual Methyl-accepting Affinity for D-Aspartyl and N-Succinyl- containing Peptides" J. Biol. Chem. 277, 1058-1065.

173. Kalhor, H. R., Luk, K., Ramos, A., Zobel-Thropp, P., and Clarke, S. (2001) "Protein Phosphatase Methyltransferase 1 (PPM1) is the Sole Activity Responsible for Modification of the Major forms of Protein Phosphatase 2A in Yeast" Arch. Biochem. Biophys. 395, 239-245.

172. Cai, H., Dumlao, D., Katz, J. E. , and Clarke, S. (2001) "Identification of the Gene and Characterization of the Activity of the trans-Aconitate Methyltransferase from Saccharomyces cerevisiae" Biochemistry 40, 13699- 13709.

171. Griffith, S. C., Sawaya, M. R., Boutz, D. R., Thapar, N., Katz, J. E., Clarke, S., and Yeates, T. O. (2001) "Crystal Structure of a Protein Repair Methyltransferase from Pyrococcus furiosus with its L-Isoaspartyl Peptide Substrate" J. Mol. Biol. 313, 1103-1116.

170. Zhang, R.-G., Skarina, T., Katz, J. E., Beasley, S., Khachatryan, A., Vyas, S., Arrowsmith, C. H., Clarke, S., Edwards, A., Joachimiak, A., and Savchenko, A. (2001) "Structure of Thermotoga maritima SurE - Stationary Phase Survival Protein - a Novel Acid Phosphatase" Structure 9, 1095-1096.

169. Branscombe, T. L., Frankel, A., Lee, J.-H., Cook, J. R., Yang, Z., Pestka, S., and Clarke, S. (2001) "PRMT5 (the Janus Kinase Binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins" J. Biol. Chem. 276, 32971-32976.

168. Clarke, S., and Banfield, K. (2001) "S-Adenosylmethionine-dependent Methyltransferases" in Homocysteine in Health and Disease (Carmel, R., and Jacobsen, D., eds), pp. 63-78.

167. Lowenson, J. D., Kim, E., Young, S. G., and Clarke, S. (2001) "Limited Accumulation of Damaged Proteins in L-Isoaspartyl (D-Aspartyl) O- Methyltransferase-deficient Mice" J. Biol. Chem. 276, 20695-20702.

166. Radkiewicz, J. L., Zipse, H., Clarke, S., and Houk, K. N. (2001) "Neighboring Side Effects on Asparaginyl and Aspartyl Degradation: An Ab Initio Study of the Relationship Between Peptide Conformation and Backbone NH Acidity" J. Amer. Chem. Soc. 123, 3499-3506.

165. Cai, H., Strouse, J., Dumlao, D., Jung, M. E., and Clarke, S. (2001) "Distinct Reactions Catalyzed by Bacterial and Yeast trans-Aconitate Methyltransferases" Biochemistry 40, 2210-2219.

164. Thapar, N., Kim, A.-K., and Clarke, S. (2001) "Distinct Patterns of Expression but Similar Biochemical Properties of Protein L-Isoaspartyl Methyltransferases in Plants" Plant Physiol. 125, 1023-1035.

163. Zobel-Thropp, P., Yang, M. C., Machado, L., and Clarke, S. (2000) "A Novel Post-translational Modification of Yeast Elongation Factor 1A: Methylesterification at the C-Terminus" J. Biol. Chem. 275, 37150-37158.

162. Thapar, N., and Clarke, S. (2000) "Expression, Purification, and Characterization of the Protein Repair L-Isoaspartyl Methyltransferase from Arabidopsis thaliana" Protein Expression Purification 20, 237-251.

161. Frankel, A., and Clarke, S. (2000) "PRMT3 is a Distinct Member of the Protein Arginine N-Methyltransferase Family: Conferral of Substrate Specificity by a Zinc-Finger Domain" J. Biol. Chem. 275, 32974-32982.

160. Yan, S. D., Zhu, Y., Zhu, H., Stern, E. D., Hwang, Y. C., Hori, O., Ogawa, S., Frosch, M. P., Connolly, E. S., Jr., McTaggert, R., Pinsky, D. J., Clarke, S., Stern, D. M., and Ramasamy, R. (2000) "Amyloid Beta-Peptide Binding Alcohol Dehydrogenase is a Component of the Cellular Response to Nutritional Stress" J. Biol. Chem. 275, 27100-27109.

159. Young, S. G., Ambroziak, P., Kim, E., and Clarke, S. (2000) "Post- isoprenylation Protein Processing: CXXX (CaaX) Endoproteases and Isoprenylcysteine Carboxyl Methyltransferase" in Protein Lipidation, a volume of The Enzymes, 3rd edition (Tamanoi, F., and Sigman, D. S., eds), 21, 155-213.

158. Bedford, M. T., Frankel, A., Yaffe, M. B., Clarke, S., Leder, P. and Richard, S. (2000) "Arginine Methylation Inhibits the Binding of Proline- rich Ligands to Src Homology 3, but not WW Domains" J. Biol. Chem. 275, 16030-16036.

157. Tang, J., Frankel, A., Cook, R. J., Kim S., Paik, W. K., Williams, K. R., Clarke, S., and Herschman, H. R. (2000) "PRMT1 is the Predominant Type I Protein Arginine Methyltransferase in Mammalian Cells" J. Biol. Chem. 275, 7723-7730.