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Steven Clarke Lab Publications - 2004 - 2007

222. Sayegh, J., Webb, K., Cheng, D., Bedford, M. T., and Clarke, S. G. (2007) “Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by its N Terminal Domain” J. Biol. Chem. 282, 36444-36453.

221. Lipson, R. S., and Clarke, S. G. (2007) “S-Adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin methylation by catechol-O-methyltransferase” J. Biol. Chem. 282, 31094-31102.

220. Pasternack, D. A., Sayegh, J., Clarke, S., and Read, L. K. (2007) "Evolutionarily Divergent Type II Protein Arginine Methyltransferase in Trypanosoma bruceii” Eukaryotic Cell 6, 1665-1681.

219. Clarke, S. G. (2007) “HIV protease inhibitors and nuclear lamin processing: getting the right bells and whistles” Proc. Natl. Acad. Sci. U. S. A. 104, 13857-13858.

218. Gomez, T. A., and Clarke, S. G. (2007) “Autophagy and Insulin/TOR Signaling in Caenorhabditis elegans pcm-1 protein repair mutants” Autophagy 3, 357- 359.

217. Chen, H., Xia, M., Lin, M., Yang, H., Kuhlenkamp, J., Li, T., Sodir, N. M., Josef-Lenz, H., Laird, P. W., Clarke, S., Mato, J., M., and Lu, S. C. (2007) “Role of Methionine Adenosyltransferase 2A and S-Adenosylmethionine in Mitogen-Induced Growth of Human Colon Cancer Cells” Gastroenterology 133, 207-218.

216. McBride, A. E., Zurita-Lopez, C., Regis, A., Blum, E., Conboy, A., Elf, S., and Clarke, S. (2007) “Protein Arginine Methylation in Candida albicans: Role in Nuclear Transport” Eukaryotic Cell 6, 1119-1129.

215. Zou, Y., Webb, K., Perna, A., Clarke, S., and Wang, Y. (2007) “A Mass Spectrometric Study on the In-vitro Methylation of HMGA1a and HMGA1b proteins by PRMTs: Methylation Specificity, the Effect of Binding to AT- rich Duplex DNA, and the Effect of C-terminal Phosphorylation” Biochemistry 46, 7896-7906.

214. Linster, C. L., Gomez, T. A., Christensen, K. C., Adler, L., Young, B. D., Brenner, C. and Clarke, S. G. (2007) "Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants." J. Biol. Chem. 282, 18879-18885. Journal of Biological Chemistry “Paper of the Week”.

213. Porras-Yakushi, T. R., Whitelegge, J. P., and Clarke, S. (2007) “Yeast Ribosomal Cytochrome c SET-domain Methyltransferase Subfamily: Identification of Rpl23ab Methylation Sites and Recognition Motifs” J. Biol Chem. 282, 12368-12376.

212. Vinci, C. R., and Clarke, S. G. (2007) “Recognition of Age-Damaged (R,S)AdoMet by Two Methyltransferases in the Yeast Saccharomyces Cerevisiae” J. Biol Chem. 282, 8604-8612.

211. Gomez, T. A., Banfield, K. L., Trogler, D. M., and Clarke, S. (2007) "The L- Isoaspartyl-O-Methyltransferase in Caenorhabditis elegans Larval Longevity and Autophagy" Develop. Biol. 303, 493-500.

210. Porras-Yakushi, T. R., Whitelegge, J. P., and Clarke, S. (2006) “A Novel SET-Domain Methyltransferase in Yeast: Rkm2-dependent Trimethylation of Ribosomal Protein L12ab at Lysine 10” J. Biol Chem. 281, 35835-35845.

209. Villa, S. T., Xu, Q., Downie, A. B., and Clarke, S. (2006) “Arabidopsis Protein Repair L-Isoaspartyl Methyltransferases: Predominant Activities at Lethal Temperatures” Physiol. Planta. 128, 581-592.

208. Vigneswara, V., Lowenson, J. D., Powell, C. D., Thakur, M., Clarke, S., Ray, D. E., and Carter, W. G. (2006) “Proteomic Identification of Novel Substrates of a Protein Isoaspartyl Methyltransferase Repair Enzyme” J. Biol. Chem. 281, 32619-32629.

207. Yang, M.-L., Doyle, H. A., Gee, R. J., Lowenson, J. D., Clarke, S., Lawson, B. R., Aswad, D. W., and Mamula, M. J. (2006) “Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity” J. Immunol. 177, 4541-4549.

206. Clarke, S. G. (2006) "Inhibition of Mammalian Protein Methyltransferases by 5'-Methylthioadenosine (MTA): A Mechanism of Action of Dietary SAMe?" in Protein Methyltransferases, a volume of The Enzymes, 3rd edition (Clarke, S. G. and Tanamoni, F., eds), 24, 467-493.

205. Young, S. G., Clarke, S. G., Bergo, M. O., Philips, M., and Fong, L. G. (2006) "Genetic Approaches for Understanding the Physiological Importance of the Carboxyl Methylation of Isoprenylated Proteins" in Protein Methyltransferases, a volume of The Enzymes, 3rd edition (Clarke, S. G. and Tanamoni, F., eds), 24, 273-301.

204. Miranda, T. B., Sayegh, J., Frankel, A., Katz, J. E., Miranda, M., and Clarke, S. (2006) "Yeast Hsl7 (histone synthetic lethal 7) Catalyzes the in vitro Formation of ?-NG-Monomethylarginine in Calf Thymus Histone H2A" Biochem. J. 395, 563-570.

203. Stetler, A., Winograd, C., Sayegh, J., Cheever, A., Patton, E., Zhang, X., Clarke, S., and Ceman, S. (2006) “Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp” Human Mol. Gen. 15, 87-96.

202. Farrar, C. E., Huang, C. S., Clarke, S. G., and Houser, C. R. (2005) "Increased Cell Proliferation and Granule Cell Number in the Dentate Gyrus of Protein Repair-Deficient Mice" J. Comparative Neurol. 493, 524-537.

201. Miranda, T. B., Webb, K. J., Edberg, D. D., Reeves, R., and Clarke, S. (2005) "Protein Arginine Methyltransferase 6 (PRMT6) Specifically Methylates the Nonhistone Chromosomal Protein HMGA1a" Biochem. Biophys. Res. Commun.
336, 831-835.

200. Porras-Yakushi, T. R., Whitelegge, J. P., Miranda, T. B., and Clarke, S. (2005) "A Novel SET-Domain Methyltransferase Modifies Ribosomal Protein Rpl23ab in Yeast" J. Biol. Chem. 280 34590-34598.

199. Lee, J., Sayegh, J., Daniel, J., Clarke, S., and Bedford, M. T. (2005) "PRMT8: A New Membrane-Bound Tissue-Specific Member of the Protein Arginine Methyltransferase Family" J. Biol. Chem. 280, 32890-32896.

198. Farrar, C. E., and Clarke, S. G. (2005) "Diet-Dependent Survival of Protein Repair-Deficient Mice" J. Nutr. Biochem. 16, 554-561.

197. Kalhor, H. R., Penjwini, M., and Clarke, S. (2005) "A Novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA" Biochem. Biophys. Res. Commun. 334, 443-440.

196. Christine E. Farrar, Carolyn R. Houser, and Steven Clarke (2005) "Activation of the PI3K/Akt Signal Transduction Pathway and Increased Levels of Insulin Receptor in Protein Repair´┐ŻDeficient Mice" Aging Cell 4, 1-12.

195. Tina B. Miranda, J. D. Lowenson, and Steven Clarke (2004) "A New Type of Protein Methylation Activated by TyrphostinA25 and Vanadate" FEBS Lett. 577, 181-186.

194. Tina Branscombe Miranda, Permanan Khusial, Jeffry R. Cook, Jin-hyung Lee, Samuel I. Gunderson, Sidney Pestka, Gary W. Zieve, and Steven Clarke. (2004) "Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus" Biochem. Biophys. Res. Commun. 323, 181-186.

193. Vinita Singh, Tina Branscombe Miranda, Wei Jiang, Adam Frankel, Martha E. Roemer, Victoria A. Robb, David H. Gutmann, Harvey R. Herschman, H. R., Steven Clarke, and Irene F. Newsham (2004) "DAL‑1/4.1B Tumor Suppressor Interacts with Protein Arginine N-Methyltransferase 3 (PRMT3) and Inhibits its Ability to Methylate Substrates in vitro and in vivo" Oncogene 23, 7761-7771.

192. Yanming Wang, Joanna Wysocka, Joyce Sayegh, Young-Ho Lee, Julie R. Perlin, Lauriebeth Leonelli, Lakshmi S. Sonbuchner, Charles H. McDonald, Richard G. Cook, Yali Dou, Robert G. Roeder, Steven Clarke, Michael R. Stallcup, C. David Allis, and Scott A. Coonrod (2004) "Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination" Science 306, 279-283.

191. Qilong Xu, Marisa P. Belcastro, Sarah T. Villa, Randy D. Dinkins, Steven G. Clarke, and A. Bruce Downie (2004) "A Second Protein L-Isoaspartyl Methyltransferase Gene in Arabidopis Produces Two Transcripts Whose Products are Sequestered in the Nucleus" Plant Physiology 136, 2552-2664.

190. Vitali, R., and Clarke, S. (2004) "Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase" Behavioral Brain Res. 153, 129-141.

189. Gary, J. D., and Clarke, S. (2004) "IadA b-Aspartyl Dipeptidase" in Handbook of Proteolytic Enzymes, 2nd edition, (eds. Woessner, G., Rawlings, N., and Barrett, A. J.), Academic Press, New York.

188. Miranda, T. B., Miranda, M., Frankel, A., and Clarke, S. (2004) "PRMT7 is a Member of the Protein Arginine Methyltransferase Family with a Distinct Substrate Specificity" J. Biol. Chem. 279, 22902-22907.

187. Katz, J. E., Dumlao, D. S., Wasserman, J. I., Lansdown, M. G., Jung, M. E., Faull, K. F., and Clarke, S. (2004) "3-Isopropylmalate is the Major Endogenous Substrate of the Saccharomyces cerevisiae trans-Aconitate Methyltransferase" Biochemistry 43, 5976-5986.

186. Boulanger, M.-C., Miranda, T. B., Clarke, S., Di Fruscio, M., Suter, B., Lasko, P., and Richard, S. (2004) "Characterization of Drosophila Protein Arginine Methyltransferases DART1 and DART4" Biochem. J. 379, 283-289.

185. Katz, J. E., Hau, J., Dumlao, D. S., and Clarke, S. (2004) "A New Technique (COMSPARI) to Facilitate the Identification of Minor Compounds in Complex Mixtures by GC/MS and LC/MS: Tools for the Visualization of Matched Datasets" J. Amer. Soc. Mass Spectrom. 15, 580-584.

184. Clarke, S., and Tamanoi, F. (2004) "Fighting Cancer by Disrupting C-Terminal Methylation of Signaling Proteins" J. Clin. Invest. 113. 513-515.