Publications from 2006 - 2009

61. Tran, U. C., Marbois, B., Gin, P., Gulmezian, M., Jonassen, T., and Clarke, C. F. (2006) “Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis” J. Biol. Chem. 281, 16401-16409.

62. Gulmezian, M., Zhang, H., Javor, G. T., and Clarke, C. F. (2006) “Genetic Evidence for an interaction of the UbiG O-methyltransferase with UbiX in Escherichia coli coenzyme Q biosynthesis” J. Bacteriol. 188, 6435-6439.

63. Hsieh, E. J., Gin, P., Gulmezian, M., Tran, U. C., Saiki, R., Marbois, B. N. and Clarke, C. F. (2007) “Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex” Arch. Biochem. Biophys. 463, 19 -26.

64. Tran, U. C., and Clarke, C. F. (2007) “Endogenous synthesis of coenzyme Q in eukaryotes” Mitochondrion. 7S, S62 -S71.

65. Gulmezian, M., Hyman, K. R., Marbois, B. N., Clarke, C. F. and Javor, G. T. (2007) "The role of UbiX in Escherichia coli coenzyme Q biosynthesis" Arch. Biochem. Biophys. 467, 144 -153.

66. Peng, M., Falk, M.J., Haase, V.H., King, R., Polyak, E., Selak, M., Yudkoff, M., Hancock, W.W., Meade, R., Saiki, R., Lunceford, A.L., Clarke, C.F., Gasser, D. L. (2008) "Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease" PLoS Genet. Apr 25;4(4):e1000061.

67. Kiebish, M.A, Han, X., Cheng, H., Lunceford, A., Clarke, C.F., Moon, H., Chuang, J.H., Seyfried, T.N. (2008) "Liipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria" J Neurochem. Jul;106(1):299-312.

68. Saiki, R., Lunceford, A.L., Bixler, T., Dang, P., Lee, W., Furukawa, S., Larsen, P.L., Clarke, C.F. (2008) "Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q" Aging Cell. Mar 26; 7:291-304.

69. Saiki, R., Lunceford, A.L., Shi, Y., Marbois, B., King, R., Pachuski, J., Kawamukai, M., Gasser, D.L., Clarke, C.F. (2008) "Coenzyme Q10 Supplementation Rescues Renal Disease in Pdss2kd/kd mice with mutations in Prenyldiphosphate synthase subunit 2" Am J Physiol Renal Physiol. Sep 10.

70. Do, T.Q., Moshkani, S., Castillo, P., Anunta, S., Pogosyan, A., Cheung, A., Marbois, B., Faull, K.F, Ernst W, Chiang SM, Fujii G, Clarke C.F., Foster K, Porter E. (2008) "Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid." J Immunol. Sep 15;181(6):4177-87.

71. Marbois, B., Gin, P., Gulmezian, M., and Clarke, C. F. (2009) "The Yeast Coq4 polypeptide organizes a mitochondrial protein complex essential for coenzyme Q biosynthesis.” Biochim. Biophys. Acta Mol. Cell. Biol. Lipid. 1791, 69-75.

72. Padilla, S., Tran, U. C., Jiménez-Hidalgo, M., López-Martín, J. M., Martín-Montalvo, A., Clarke, C. F., Navas, P., Santos-Ocaña, C. (2009) “Hydroxylation of Demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis.” Cell. Mol. Life Sci. 66, 173-186.

73. Padilla-López, S., Jiménez-Hidalgo, M., Martín-Montalvo, A., Clarke, C. F., Navas, P., and Santos-Ocaña, C. (2009) “Genetic evidence for the requirement of an endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae.” Biochim. Biophys. Acta 1788, 1238-1248.

74. Cristina, D., Cary, M., Lunceford, A., Clarke, C., and Kenyon, C. (2009) “A regulated response to impaired respiration slows behavioral rate and increases lifespan in Caenorhabditis elegans.” PLOS Genetics 5(4): e1000450.

75. Lomenick, B., Hao, R., Jonai, N., Chin, R. M., Aghajan, M., Warburton, S., Wang, J., Wu, R. P., Gomez, F., Loo, J. A., Wohlschlegel, J. A., Vondriska, T. M., Pelletier, J., Herschman, H. R., Clardy, J., Clarke, C. F., and Huang, J. (2009) “Target identification using drug affinity responsive target stability (DARTS).” Proc. Natl. Acad. Sci. USA 106, 21984-21989.