Publications from 2001 - 2005

44. Jonassen, T., Larsen, P. L. and Clarke, C. F. (2001) "A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants." Proc. Natl. Acad. Sci. U.S.A. 98, 421-426.4. PMCID: PMC14601

45. Do, T. Q., Hsu, A. Y., Jonassen, T., Lee, P. T., and Clarke, C. F. (2001) "A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants." J. Biol. Chem. 276, 18161-18168.

46. Belogrudov, G. I., Lee, P. T., Jonassen, T., Hsu, A. Y., Gin, P., and Clarke, C. F. (2001) "Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q biosynthesis." Arch. Biochem. Biophys. 392, 48-58.

47. Larsen, P. L. and Clarke, C. F. (2002) "Extension of Life-Span in Caenorhabditis elegans by a diet lacking coenzyme Q." Science, 4 Vol. 295 no. 5552 pp. 120-123.

48. Santos-Ocana, C., Do, T. Q., Padilla, S., Navas, P. and Clarke, C. F. (2002) "Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants." J. Biol. Chem. 277, 10973-10981.

49. Jonassen, T., Marbois, B. N., Faull, K. F., Clarke, C. F. and Larsen, P. L. (2002) "Development and fertility in C. elegans clk-1 mutants depends upon transport of dietary coenzyme Q8 to mitochondria." J. Biol. Chem. 277, 45020-45027.

50. Gin, P. Hsu, A.Y., Rothman, S., Jonassen, T., Lee, P.T., Tzagoloff, A. and Clarke, C.F. (2003) "The Saccharomyces cerevisiae COQ6 gene encodes a flavin dependent monooxygenase required for coenzyme Q biosynthesis." J. Biol. Chem. 278, 25308-25316.

51. Jonassen, T., Davis, D. E., Larsen, P. L., and Clarke, C. F. (2003) "Reproductive fitness and quinonecontent of C. elegans clk-1 mutants fed coenzyme Q isoforms of varying length." J. Biol. Chem. 278, 51735-51742.

52. Baba, S.W., Belogrudov, G.I., Lee, J.C., Lee, P.T., Strahan, J., Shepherd, J.N., Clarke, C.F. (2004) "Yeast coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme q biosynthesis." J. Biol Chem. Mar 12;279(11):10052-9.

53. Esteves, T. C., Echtay, K. S., Jonassen, T., Clarke C. F., and Brand, M. D. (2004) "Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria". Biochem. J. 379, 309-315.

54. Hsieh, E. J., Dinoso, J. B., and Clarke, C. F. (2004) "A tRNA-TRP gene mediates the suppression of cbs2-223 previously attributed to ABC1/COQ8." Biochem. Biophys. Res. Commun. 317, 648-653.

55. Padilla, S., Jonassen, T., Jimenez-Hidalgo, M. J., Fernandez-Ayala, D. J. M., Lopez-Lluch, G. M., Marbois, B., Navas, P., Clarke, C. F. and Santos-Ocana, C. (2004) "Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cervisiase and lacks antioxidant activity". J. Biol. Chem. 279, 25995-26004.

56. Dyall, S.D., Yan, W., Delgadillo-Correa, M.G., Lunceford, A., Loo, J.A., Clarke, C.F., Johnson, P.J. (2004) "Non-mitochondrial complex I proteins in a hydrogenosomal oxidoreductase complex." Nature. Oct 28;431(7012):1103-7.

57. Gin, P., Clarke, C.F. (2004) "Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase." J Biol Chem. Jan 28;280(4):2676-81.

58. Marbois, B., Gin, P., Faull, K.F., Poon, W.W., Lee, P.T., Strahan, J., Shepherd, J.N., Clarke, C.F. (2005) "Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q." J Biol Chem. May 27;280(21):20231-8.

59. Johnson, A., Gin, P., Marbois, B.N., Hsieh, E.J., Wu, M., Barros, M.H., Clarke, C.F., Tzagoloff, A. (2005) "COQ9, a New Gene Required for the Biosynthesis of Coenzyme Q in Saccharomyces cerevisiae." J Biol Chem. Sep 9;280(36):31397-404.

60. Barros, M. H., Johnson, A., Gin, P., Marbois, B. N., Clarke, C. F. and Tzagoloff, A. (2005) “The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration.” J. Biol. Chem. 280, 42627-42635.